Abstract
INTRODUCTION: after the age of 50 the incidence of the novo seizures increases with each decade, leading to a prevalence of around 1.2% in patients over 60 years. This age group is 6.5% of the Colombian population, which allows us to calculate that in the country about 35,000 people in this age range have epilepsy, often underdiagnosed because the usual clinical presentation is different from other age groups.
OBJECTIVE: to describe the sociodemographic, clinical and paraclinical characteristics of the population over 60 years with the novo seizures in a neurological center of reference in the city of Cali.
MATERIALS AND METHODS: a descriptive retrospective study. Analysis of variables using frequencies, means and proportions.
RESULTS: sample 51 patients. Average age: 73 years. 47.1% had a history of hypertension, 37.3% had one or multiple cerebrovascular attacks ,events either as a clearly defined clinical picture, or just evidence of microangiopathic brain lesions. Seizures were focal in 60.7% of the patients, of whom 76.4% received pharmacological treatment with valproic acid as monotherapy and 90.2% of them is controlled.
CONCLUSION: in the population over 60 years, epilepsy occurs usually with a semiology of crisis different to that of other age groups, which should be taken into account during the medical consultation in order to identify them through a detailed medical history. It was found that low-dose valproic acid was an effective and safe drug in this population where the most common cause is cerebrovascular disease (CVD).
References
LASSO J, CABELLO E, JURI C, VARGAS A, VALENZUELA M, LEIGTON R. Epilepsia y tercera edad: Descripción de una serie del Hospital Padre Hurtado. Revista Chilena de Epilepsia 2005; 6:12-14.
PALAU PÉREZ LD, VÉLEZ VAN MEERBEKE A, GUTIÉRREZ ÁLVAREZ AM, QUINTERO P, ORTIZ SALAS P, SOBRINO F. Caracterización de pacientes adultos mayores con epilepsia en dos hospitales en Bogotá,Colombia.2010; http://repository.urosario.edu.co/bitstream/10336/1727/1/80184796.pdf
DE LA COURT A, BRETELER MM, MEINARDI H, HAUSER WA, HOFMAN A. Prevalence of epilepsy in the elderly: the Rotterdam Study. Epilepsia 1996;37:141-7.
DANE. Proyecciones nacionales y departamentales de población. 2006-2020. Bogotá 2007. En URL: http://www dane.govco/files/investigaciones/poblacion/proyepobla06_20/7Proyecciones_pobla-cion.pdf
VELEZ A, ESLAVA-COBOS J. Epilepsy in Colombia: epidemiologic profile and classification of epileptic seizures and syndromes. Epilepsia 2006;47:193-201.
THOMSON A, BELEN VIAGGIO M. Epilepsia en la tercera edad. Revista Neurológica Argentina 2002;27(2):109-117.
ASCONAPE JJ, PENRY JK. Poststroke seizures in the elderly. Clin Genatr Med 1991;7:483-92.
NG SK, HAUSER WA, BRUST JC, SUSSER M. Hypertension and risk of newonset unprovoked seizures. Neurology 1993;43:425-8.
MAURI-LLERDA JA, TEJERO-JUSTE C. Epilepsia vascular. Revista Epilepsia SEN 2009;2:1-8.
STEPHEN L, BRODIE M. Epilepsy in older people. Lancet 2000;355:1441-6.
FORTEA-CABO G. Orientación diagnóstica en las crisis epilépticas en el anciano. 2007. http://www.moliner.san.gva.es/castellano/Docencia/Cri-sisEpilecticas.pdf. HospitalDoctorMoliner. España.
SIRVEN JI, OZUNA J. Diagnosing epilepsy in older adults: What does it mean for primary care physician?. Geriatrics 2005;60:30-5.
HOLMES G. The electroencephalogram as a predictor of seizure following cerebral infarction. Clin electroencephalograph 1980;11:83-6.
BERGEY GK. Initial treatment of epilepsy. Special issues in treating the elderly. Neurology 2004;63(Suppl 4):S40-8.
SERRANO-CASTRO PJ, RAMOS-LIZANA J, PITA-CALANDRE E, CAMINO-LEÓN R, GALÁN-BARRANCO JM, RUFO-CAMPOS M, ET AL. Criterios de inicio y cese: bases farmacológicas del tratamiento antiepiléptico. Rev Neurol 2005;40:56371.
POZA-ALDEA JJ. Epilepsia en ancianos. Rev Neurol 2006;42:42-46.
LEPPIK IE. Treatment of epilepsy in the elderly. Curr Treat Options Neurol 2008;10:239-45.
CLOYD J, HAUSER W, TOWNE A, RAMSAY R, MATTSON R, GILLIAM F, ET AL. Epidemiological and medical aspects of epilepsy in the elderly. Epilepsy Res 2006;68(Suppl 1):S39-48.
RAMSAY RE, ROWAN AJ, PRYOR FM. Special considerations in treating the elderly patient with epilepsy. Neurology 2004;62(Suppl 2):S24-9.
HAUSER WA, ANNEGERS JF, KURLAND LT. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia 1993;34:453-68.
RAMSAY RE, MACIAS FM, ROWAN AJ. Diagnosing epilepsy in the elderly. Int Rev Neurobiol. 2007;81:129-51.
BENDER DEL BUSTO JE, ÁLVAREZ-GONZÁLEZ E, RODRÍGUEZ-MUTUBERRÍA L. Enfermedad cerebrovascular y epilepsia. Análisis casuístico CIREN. Rev Mex Neuroci 2006; 7:325-329.
MARASCO RA, RAMSAY RE. Defining and diagnosing epilepsy in the elderly. Consult Pharm 2009;24(Suppl A):5-9.
MATTSON RH, CRAMER JA, COLLINS JF, SMITH DB, DELGADO-ESCUETA AV, BROWNE TR, WILLIAMSON PD, TREIMAN DM, MCNA-MARA JO, MCCUTCHEN CB, ET AL. Comparison of Carbamazepine, Phenobarbital, Phenytoin, and Primidone in partial and secondarily generalized tonic-clonic seizures. N Engl J Med 1985;313:145-51.
BRODIE MJ, ELDER AT, KWAN P. Epilepsy in later life. Lancet Neurol 2009; 8:1019-30.

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