Encephalopathy and bilateral globus pallidum infarction secondary to disulfiram poisoning. Case Reports in Pediatrics
PDF (Español)
HTML (Español)

Keywords

Basal Ganglia
Disulfiram Intoxication
Globus Pallidum
Neurotoxicity (MeSH)

Abstract

Disulfiram (Antabuse ®) is a drug that is widely used in patients with chronic alcohol consumption as part of treatment for alcoholism, in order to produce unpleasant symptoms when mixed with ethanol, acetaldehyde increased.

Although there have been cases of poisoning even without alcohol intake at therapeutic doses and overdose most commonly in adults, few cases have been reported in children. We present a Child with disulfiram intoxication, who presented in acute sleepiness, progressing to stupor concomitantly presented seizures, vomiting, dehydration, rigidity, tremor and sweating; in output with severe neurological sequelae characterized by bilateral dystonia and pyramidal signs as a result of bilateral basal ganglia lesion documented by imaging.

https://doi.org/10.22379/2422402242

PDF (Español)
HTML (Español)

References

SUH JJ, PETTINATI HM, KAMPMAN KM, O'BRIEN CHP. The Status of Disulfiram A Half of a Century Later. J Clin Psychopharmacol 2006;26:290-302.

MOHAPATRA S, SAHOO MR, RATH N. Disulfiram-induced neuropathy: a case report. General Hospital Psychiatry 2015;37:97.e5-97.e6.

ROTHMANN S, OLNEY J. Glutamate and the pathophysiology of hypoxicischemia damage. Ann Neurol. 1986;19:105-11.

LAPLANE D, ATTAL N, SAURON B, BILLY A DE, DUBOIS B. Lesions of basal ganglia due to disulfiram Neurotoxicity. Journal of Neurology, Neurosurgery, and Psychiatry 1992;55:925-9.

RILEY D. Pallidal and putaminal lesions resulting from disulfiram intoxication. Mov Disord. 1992;7(2):188.

LEMOYNE S, RAEMAKERS J, DAEMS J, HEYTENS L. Delayed and prolonged coma after acute disulfiram overdose. Acta Neurol Belg. 2009;109:231?4.

KOSTEN TR, WU G, HUANG W, HARDING MJ, HAMON SC, LAPPALAINEN J, NIELSEN DA. Pharmacogenetic randomized trial for cocaine abuse: Disulfiram and dopamine beta hydroxylase. Biol Psychiatry 2013;73:219?24.

CHUANG WL, HUANG CC, CHEN CJ, HSIEH YC, KUO HC, SHIH TS. Carbon disulfide encephalopathy: Cerebral microangiopathy. Neurotoxicology 2007;28:387?93.

PARK JW, CHUNG SW, LEE SJ, LEE KS, KIM BS. Selective vulnerability of nigrostriatopallidal dopaminergic pathway after disulfiram intoxication: Two cases with clinical and magnetic resonance study. Eur J Radiol Extra 2003;46:1?5.

ZARZA B, MARTÍNEZ-CASTRILLO JC, LUQUE M, MASJUAN-VALLEJO J. Acute encephalopathy secondary to treatment with disulfiram. Rev Neurol. 2007;45(7):444-5.

KULKARNI RR; PRADEE AV; BAIRY BK. Disulfiram-Induced Combined Irreversible Anterior Ischemic Optic Neuropathy and Reversible Peripheral Neuropathy: A Prospective Case Report and Review of the Literature. J Neuropsychiatry Clin Neurosci. 2014;25:4.

ALHARBI FF, EL-GUEBALY N. The relative safety of disulfiram. Addict Disord Their Treatment 2013;12:140-7.

Kuffner EK. Disulfiram and disulfiram like reactions. In: Lewis S. Nelson. Goldfrank's toxicology Emergencies. 9th ed. New York: McGraw-Hill Medical; 2011. p. 1143-8.

SÈZE J DE, CAPARROS-LEFEBVRE D, NKENJUO JB, HURTEVENT JF, PETIT H. Acute and reversible myoclonic encephalopathy, extrapyramidal syndrome, polyneuropathy caused by chronic disulfiram poisoning. Rev Neurol. (Paris) 1995 Nov;151(11):667-9.

MAHAJAN P, LIEH-LAI MW, SARNAIK A, KOTTAMASU SR. Basal ganglia infarction in a child with disulfiram poisoning. Pediatrics 1997;99(4):605-8.

MESIWALA AH, LOESER JD. Bilateral globus pallidus infarction secondary to disulfiram ingestion. Pediatr Neurosurg. 2001;34(4):224.

VYKUNTARAJU KN, RAMALINGAIAH AH. Disulfiram poisoning causing acute encephalopathy. Indian Pediatr. 2013;50(9):887-8.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Downloads

Download data is not yet available.