Abstract
OBJECTIVE:
To determine the prescription pattern of riluzol and the variables associated to its use in a population of patients with motor neuron disease affiliated to the Colombian General Social Security Health System (SGSSS) in 2017.
METHOD:
Descriptive cross-sectional study. Through a systemized data base of approximately 3,5 million members to the Colombian SGSSS; patients who had been given riluzol uninterruptedly between April 1 and June 30 of 2017, were selected. Sociodemographic, pharmacological variables and comorbidities were analyzed. Defined daily dose (DDD) was estimated for 1.000 inhabitants/day and its costs.
RESULTS:
There were found 81 patients with motor neuron disease receiving riluzol, with an average age of 60,8+12,6 years. 48.1% were male. The prevalence of motor neuron disease was 29/100.000 individuals. Patients received riluzol in 50 mg tablets and the doses was estimated in 0,016 DDD for 1.000 inhabitants/day 63% were receiving medicines that reflect comorbidity or could interact with riluzol. The total cost of riluzol dispensed in 2017 was USD 85.348 and per prescribed daily dose on average was USD 2,3.
CONCLUSIONS:
The use of riluzol in patients with motor neuron disease in Colombia was carried by the recommended doses by the WHO and with a direct cost lower than reported in other countries. Studies are recommended in order to determine the effectiveness of riluzol in real-life conditions.
References
Zapata-Zapata CH, Franco-Dáger E, Solano-Atehortúa JM, Ahunca-Velásquez LF. Esclerosis lateral amiotrófica: actualización. Iatreia. 2016;29(2).
Calvo AC, Manzano R, Mendonca DM, Munoz MJ, Zaragoza P, Osta R. Amyotrophic lateral sclerosis: a focus on disease progression. Biomed Res Int. 2014;2014:925101.
Kiernan MC, Vucic S, Cheah BC, Turner MR, Eisen A, Hardiman O, et al. Amyotrophic lateral sclerosis. Lancet. 2011;377(9769):942-55.
Beghi E, Logroscino G, Chio A, Hardiman O, Mitchell D, Swingler R, et al. The epidemiology of ALS and the role of population-based registries. Biochim Biophys Acta. 2006;1762(11-12):1150-7.
Chio A, Logroscino G, Traynor BJ, Collins J, Simeone JC, Goldstein LA, et al. Global epidemiology of amyotrophic lateral sclerosis: a systematic review of the published literature. Neuro-epidemiology. 2013;41(2):118-30.
Vazquez MC, Ketzoian C, Legnani C, Rega I, Sanchez N, Perna A, et al. Incidence and prevalence of amyotrophic lateral sclerosis in Uruguay: a population-based study. Neuroepidemiology. 2008;30(2):105-11.
Zapata-Zapata CH, Franco Dáger E, Aguirre-Acevedo DC, de Carvalho M, Solano-Atehortúa J. Prevalence, Incidence, and Clinical-Epidemiological Characterization of Amyotrophic Lateral Sclerosis in Antioquia: Colombia. Neuroepidemiology. 2020;54(3):251-7.
Traxinger K, Kelly C, Johnson BA, Lyles RH, Glass JD. Prognosis and epidemiology of amyotrophic lateral sclerosis: Analysis of a clinic population, 1997-2011. Neurol Clin Pr. 2013;3(4):313-20.
Pandya RS, Zhu H, Li W Bowser R, Friedlander RM, Wang X. Therapeutic neuroprotective agents for amyotrophic lateral sclerosis. Cell Mol Life Sci. 2013;70(24):4729-45.
Valadi N. Evaluation and management of amyotrophic lateral sclerosis. Prim Care. 2015;42(2):177-87.
Bensimon G, Lacomblez L, Meininger V A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. N Engl J Med. 1994;330(9):585-91.
Larkindale J, Yang W, Hogan PF, Simon CJ, Zhang Y, Jain A, et al. Cost of illness for neuromuscular diseases in the United States. Muscle Nerve. 2014;49(3):431-8.
Gladman M, Zinman L. The economic impact of amyotrophic lateral sclerosis: a systematic review. Expert Rev Pharmacoecon Outcomes Res. 2015;15(3):439-50.
Obermann M, Lyon M. Financial cost of amyotrophic lateral sclerosis: A case study. Amyotroph Lateral Scler Front Degener. 2015;16(1-2):54-7.
Logroscino G, Traynor BJ, Hardiman O, Chio A, Mitchell D, Swingler RJ, et al. Incidence of amyotrophic lateral sclerosis in Europe. J Neurol Neurosurg Psychiatry. 2010;81(4):385-90.
Martinez HR, Molina-Lopez JF, Cantu-Martinez L, Gonzalez-Garza MT, Moreno-Cuevas JE, Couret-Alcaraz P, et al. Survival and clinical features in Hispanic amyotrophic lateral sclerosis patients. Amyotroph Lateral Scler. 2011;12(3):199-205.
Bucheli M, Andino A, Montalvo M, Cruz J, Atassi N, Berry J, et al. Amyotrophic lateral sclerosis: analysis of ALS cases in a predominantly admixed population of Ecuador. Amyotroph Lateral Scler Front Degener. 2014;15(1-2):106-13.
Huisman MH, de Jong SW, van Doormaal PT, Weinreich SS, Schelhaas HJ, van der Kooi AJ, et al. Population based epidemiology of amyotrophic lateral sclerosis using capture-recapture methodology. J Neurol Neurosurg Psychiatry. 2011;82(10):1165-70.
O'Toole O, Traynor BJ, Brennan P, Sheehan C, Frost E, Corr B, et al. Epidemiology and clinical features of amyotrophic lateral sclerosis in Ireland between 1995 and 2004. J Neurol Neurosurg Psychiatry. 2008;79(1):30-2.
Wittie M, Nelson LM, Usher S, Ward K, Benatar M. Utility of capture-recapture methodology to assess completeness of amyotrophic lateral sclerosis case ascertainment. Neuroepidemiology. 2013;40(2):133-41.
Bertakis KD, Azari R, Helms LJ, Callahan EJ, Robbins JA. Gender differences in the utilization of health care services. J Fam Pract. 2000;49(2):147-52.
Machado-Alba JE, Calvo-Torres LF, Gaviria-Mendoza A, Augusto Meji AVC. Prescription profile of pyridostigmine use in a population of patients with myasthenia gravis. Muscle Nerve. 2017;56(6):1041-6.
Cronin S, Hardiman O, Traynor BJ. Ethnic variation in the incidence of ALS: A systematic review Neurology. 2007;68(13):1002-7.
Lacomblez L, Bensimon G, Leigh PN, Guillet P, Meininger V. Doseranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II. Lancet. 1996;347(9013):1425-31.
Cetin H, Klickovic U, Rath J, Zulehner G, Fuzi J, Reichardt B, et al. Associations between co-medications and survival in ALS-a cohort study from Austria. J Neurol. 2015;262(7):1698-705.
Grande G, Morin L, Vetrano DL, Fastbom J, Johnell K Drug use in older adults with amyotrophic lateral sclerosis near the end of life. Drugs Aging. 2017;34(7):529-33.
Korner S, Kollewe K, Ilsemann J, Muller-Heine A, Dengler R, Krampfl K, et al. Prevalence and prognostic impact of comorbidities in amyotrophic lateral sclerosis. Eur J Neurol. 2013;20(4):647-54.
Chio A, Canosa A, Gallo S, Moglia C, Ilardi A, Cammarosano S, et al. Pain in amyotrophic lateral sclerosis: a population-based controlled study. Eur J Neurol. 2012;19(4):551-5.
Stephens HE, Joyce NC, Oskarsson B. National study of muscle cramps in ALS in the USA. Amyotroph Lateral Scler Front Degener. 2017;18(1-2):32-6.
Dupuis L, Corcia P, Fergani A, Gonzalez De Aguilar JL, Bonnefont-Rousselot D, Bittar R, et al. Dyslipidemia is a protective factor in amyotrophic lateral sclerosis. Neurology. 2008;70(13):1004-9.
Zinman L, Sadeghi R, Gawel M, Patton D, Kiss A. Are statin medications safe in patients with ALS? Amyotroph Lateral Scler. 2008;9(4):223-8.
Sorensen HT, Lash TL. Statins and amyotrophic lateral sclerosis--the level of evidence for an association. J Intern Med. 2009;266(6):520-6.
Ilzecka J, Stelmasiak Z. Thyroid function in patients with amyotrophic lateral sclerosis. Ann Univ Mariae Curie Sklodowska Med. 2003;58(1):343-7.
Zheng Z, Guo X, Huang R, Chen X, Shang H. An exploratory study of the association between thyroid hormone and survival of amyotrophic lateral sclerosis. Neurol Sci. 2014;35(7):1103-8.
Moore A, Young CA, Hughes DA. Economic studies in motor neurone disease: A systematic methodological review. Pharmacoeconomics. 2017;35(4):397-413.
van der Steen I, van den Berg JP, Buskens E, Lindeman E, van den Berg LH. The costs of amyotrophic lateral sclerosis, according to type of care. Amyotroph Lateral Scler. 2009;10(1):27-34.
Schepelmann K, Winter Y, Spottke AE, Claus D, Grothe C, Schroder R, et al. Socioeconomic burden of amyotrophic lateral sclerosis, myasthenia gravis and facioscapulohumeral muscular dystrophy. J Neurol. 2010;257(1):15-23.
Camacho A, Esteban J, Paradas C. Report by the Spanish Foundation for the Brain on the social impact of amyotrophic lateral sclerosis and other neuromuscular disorders. Neurologia. 2018;33(1):35-46.
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