Abstract
Since the 1970s, the availability of structural neuroimaging (computed tomography and magnetic resonance imaging) and functional neuroimaging (single photon emission computed tomography (SPECT), positron emission tomography (PET), functional magnetic resonance imaging (fMRI)), has opened a new way in the study of the bidirectional relationship between behavioral phenomena and neuronal activity. The introduction of these techniques led to a better understanding of the impact of a brain injury on cortical activity and on the development of psychiatric symptoms. It is difficult to explain affective symptoms as a consequence of a brain structure dysfunction and is important to consider a brain circuit impairment. Many affective disorders have been associated with lesions in thalamolymbic connections, including major depressive disorder, obsessive-compulsive disorder, addiction to psychoactive substances and post-traumatic stress disorder, and the identification of the connectivity tracts can provide new means for effective therapeutic intervention.
References
Barrett J, Della-Maggiore V, Chouinard PA, Paus T. Mechanisms of action underlying the effect of repetitive transcranial magnetic stimulation on mood: behavioral and brain imaging studies. Neuropsychopharmacology. 2004;29(6):1172-89.
Clark DL, Boutros NN. The brain and behavior: an introduction to behavioral neuroanatomy. Cambridge : Cambridge University Press, 2010; 2017.
Jonasson L, Hagmann P, Pollo C, Bresson X, Richero Wilson C, Meuli R, et al. A level set method for segmentation of the thalamus and its nuclei in DT-MRI. Signal Processing. 2007;87(2):309-21.
Yang S, Hua P, Shang X, Cui Z, Zhong S, Gong G, et al. A significant risk factor for poststroke depression: the depression-related subnetwork. J Psychiatry Neurosci. 2015;40(4):259-68.
Coenen VA, Panksepp J, Hurwitz TA, Urbach H, Madler B. Human medial forebrain bundle (MFB) and anterior thalamic radiation (ATR): imaging of two major subcortical pathways and the dynamic balance of opposite affects in understanding depression. J Neuropsychiatry Clin Neurosci. 2012;24(2):223-36.
Wilson HD, Uhelski ML, Fuchs PN. Examining the role of the medial thalamus in modulating the affective dimension of pain. Brain Res. 2008;1229:90-9.
Perea-Bartolomé MV, Ladera-Fernández V. El tálamo: aspectos neurofuncionales. RevNeurol. 2004;38(07):0687-93.
Monroy Rojas S, Jiménez Orozco L, Meza Cely N, Salcedo J. Infarto talámico bilateral por obstrucción de la arteria de Percherón: reporte de caso. Acta Neurol Colomb. 2017;33( 2):104-14.
Schmahmann JD. Vascular syndromes of the thalamus. Stroke. 2003;34(9):2264-78.
Wolff M, Alcaraz F, Marchand AR, Coutureau E. Functional heterogeneity of the limbic thalamus: From hippocampal to cortical functions. Neurosci Biobehav Rev. 2015;54:120-30.
Vertes RP, Linley SB, Hoover WB. Limbic circuitry of the midline thalamus. Neurosci Biobehav Rev. 2015;54:89-107.
Price JL, Drevets WC. Neurocircuitry of mood disorders. Neuropsychopharmacology. 2010;35(1):192-216.
Fair DA, Bathula D, Mills KL, Dias TG, Blythe MS, Zhang D, et al. Maturing thalamocortical functional connectivity across development. Front Syst Neurosci. 2010;4:10.
Morishita T, Fayad SM, Higuchi MA, Nestor KA, Foote KD. Deep brain stimulation for treatment-resistant depression: systematic review of clinical outcomes. Neurotherapeutics. 2014;11(3):475-84.
Carrera E, Bogousslavsky J. The thalamus and behavior: effects of anatomically distinct strokes. Neurology. 2006;66(12):1817-23.
Frodl T, Janowitz D, Schmaal L, Tozzi L, Dobrowolny H, Stein DJ, et al. Childhood adversity impacts on brain subcortical structures relevant to depression. J Psychiatr Res. 2017;86:58-65.
Zhao YJ, Du MY, Huang XQ, Lui S, Chen ZQ, Liu J, et al. Brain grey matter abnormalities in medication-free patients with major depressive disorder: a meta-analysis. Psychol Med. 2014;44(14):2927-37.
Kong L, Wu F, Tang Y, Ren L, Kong D, Liu Y, et al. Frontal-sub-cortical volumetric deficits in single episode, medication-naive depressed patients and the effects of 8 weeks fluoxetine treatment: A VBM-DARTEL study. PLoS ONE. 2014;9(1):e79055.
Sexton CE, MacKay CE, Ebmeier KP. A systematic review and meta-analysis of magnetic resonance imaging studies in late-life depression. Am J Geriatr Psychiatry. 2013;21(2):184-95.
Vasic N, Walter H, Hose A, Wolf RC. Gray matter reduction associated with psychopathology and cognitive dysfunction in unipolar depression: a voxel-based morphometry study. J Affect Disord. 2008;109(1-2):107-16.
Turner AD, Furey M, Drevets WC, Zarate C, Nugent A. Association between subcortical volumes and verbal memory in unmedicated depressed patients and healthy controls. Neuropsychologia. 2012;50(9):2348-55.
Kim MJ, Hamilton JP, Gotlib IH. Reduced caudate gray matter volume in women with major depressive disorder. Psychiatry Res. 2008;164(2):114-22.
Goodkind M, Eickhoff SB, Oathes DJ, Jiang Y, Chang A, Jones-Hagata LB, et al. Identification of a common neurobiological substrate for mental Illness. JAMA Psychiatry. 2015;72(4):305-15.
Kempton MJ, Salvador Z, Munafo MR, Geddes JR, Simmons A, Frangou S, et al. Structural neuroimaging studies in major depressive disorder. Meta-analysis and comparison with bipolar disorder. Arch Gen Psychiatry. 2011;68(7):675-90.
Bora E, Harrison BJ, Davey CG, Yucel M, Pantelis C. Meta-analysis of volumetric abnormalities in cortico-striatal-pallidal-thalamic circuits in major depressive disorder. Psychol Med. 2012;42(4):671-81.
Yu K, Cheung C, Leung M, Li Q, Chua S, McAlonan G. Are bipolar disorder and schizophrenia neuroanatomically distinct? An anatomical likelihood meta-analysis. Front Hum Neurosci. 2010;4:189.
Haznedar M, Roversi F, Pallanti S, Baldini-Rossi N, Schnur DB, Licalzi EM, et al. Frontothalamo-striatal gray and white matter volumes and anisotropy of their connections in bipolar spectrum illnesses. Biol Psychiatry. 2005;57(7):733-42.
Adler CM, DelBello MP, Jarvis K, Levine A, Adams J, Strakowskio SM, et al. Voxel-based study of structural changes in first-episode patients with bipolar disorder. Biol Psychiatry. 2007;61(6):776-81.
Fornito A, Yucel M, Pantelis C. Reconciling neuroimaging and neuropathological findings in schizophrenia and bipolar disorder. Curr Opin Psychiatry. 2009;22(3):312-9.
Miller CH, Hamilton JP, Sacchet MD, Gotlib IH. Meta-analysis of functional neuroimaging of major depressive disorder in youth. JAMA Psychiatry. 2015;72(10):1045-53.
Neumeister A, Nugent AC, Waldeck T, Geraci M, Schwarz M, Bonne O, et al. Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls. Arch Gen Psychiatry. 2004;61(8):765-73.
Diener C, Kuehner C, Brusniak W, Ubl B, Wessa M, Flor H. A meta-analysis of neurofunctional imaging studies of emotion and cognition in major depression. NeuroImage. 2012;61(3):677-85.
Jaworska N, Yang XR, Knott V, MacQueen G. A review of fMRI studies during visual emotive processing in major depressive disorder. World J Biol Psychiatry. 2015;16(7):448-71.
Wang L, Hermens DF, Hickie IB, Lagopoulos J. A systematic review of resting-state functional-MRI studies in major depression. J Affect Disord. 2012;142(1-3):6-12.
Su L, Cai Y, Xu Y, Dutt A, Shi S, Bramon E. Cerebral metabolism in major depressive disorder: a voxel-based meta-analysis of positron emission tomography studies. BMC Psychiatry. 2014;14:321.
Delvecchio G, Fossati P, Boyer P, Brambilla P, Falkai P, Gruber O, et al. Common and distinct neural correlates of emotional processing in Bipolar disorder and major depressive disorder: a voxel-based meta-analysis of functional magnetic resonance imaging studies. Eur Neuropsychopharmacol. 2012;22(2):100-13.
Bruhl AB, Jancke L, Herwig U. Differential modulation of emotion processing brain regions by noradrenergic and serotonergic antidepressants. Psychopharmacology (Berl). 2011;216(3):389-99.
Brody AL, Saxena S, Stoessel P, Gillies LA, Fairbanks LA, Alborzian S, et al. Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: preliminary findings. Arch Gen Psychiatry. 2001;58(7):631-40.
Wen MC, Chan LL, Tan LCS, Tan EK. Depression, anxiety, and apathy in Parkinson's disease: Insights from neuroimaging studies. Eur J Neurol. 2016;23(6):1001-19.
Velasco F, Velasco M, Jimenez F, Velasco AL, Salin-Pascual R. Neurobiological b ackground for performing surgical intervention in the inferior thalamic peduncle for treatment of major depression disorders. Neurosurgery. 2005;57(3):439-48.
Bauer M, Berman S, Stamm T, Plotkin M, Adli M, Pilhatsch M, et al. Levothyroxine effects on depressive symptoms and limbic glucose metabolism in bipolar disorder: A randomized, placebo-controlled positron emission tomography study. Mol Psychiatry. 2016;21(2):229-36.
Smith GS, Ma Y, Dhawan V, Gunduz H, Carbon M, Kirshner M, et al. Serotonin modulation of cerebral glucose metabolism measured with positron emission tomography (PET) in human subjects. Synapse. 2002;45(2):105-12.
Blumberg HP, Martin A, Kaufman J, Leung HC, Skudlarski P, Lacadie C, et al. Frontostriatal abnormalities in adolescents with bipolar disorder: preliminary observations from functional MRI. Am J Psychiatry. 2003;160(7):1345-7.
Pavuluri MN, Passarotti AM, Harral EM, Sweeney JA. Enhanced prefrontal function with pharmacotherapy on a response inhibition task in adolescent bipolar disorder. J Clin Psychiatry. 2010;71(11):1526-34.
Jiang J, Zhao YJ, Hu XY, Du MY, Chen ZQ, Wu M, et al. Microstructural brain abnormalities in medication-free patients with major depressive disorder: A systematic review and meta-analysis of diffusion tensor imaging. J Psychiatry Neurosci. 2017;42(3):150-63.
Jenkins LM, Barba A, Campbell M, Lamar M, Shankman SA, Leow AD, et al. Shared white matter alterations across emotional disorders: A voxel-based meta-analysis of fractional anisotropy. NeuroImage: Clinical. 2016;12:1022-34.
Buchsbaum MS, Wu J, Siegel BV, Hackett E, Trenary M, Abel L, et al. Effect of sertraline on regional metabolic rate in patients with affective disorder. Biol Psychiatry. 1997;41(1):15-22.
Zobel A, Joe A, Freymann N, Clusmann H, Schramm J, Reinhardt M, et al. Changes in regional cerebral blood flow by therapeutic vagus nerve stimulation in depression: An exploratory approach. Psychiatry Res. 2005;139(3):165-79.
Davies J, Lloyd KR, Jones IK, Barnes A, Pilowsky LS. Changes in regional cerebral blood flow with venlafaxine in the treatment of major depression. Am J Psychiatry. 2003;160(2):374-6.
Mayberg HS, Lewis PJ, Regenold W, Wagner HN, Jr. Paralimbic hypoperfusion in unipolar depression. J Nucl Med. 1994;35(6):929-34.
Charyton C, Elliott JO, Moore JL, Klatte ET. Is it time to consider cognitive behavioral therapy for persons with epilepsy? Clues from pathophysiology, treatment and functional neuroimaging. Expert Rev Neurother. 2010;10(12):1911-27.
Lisiecka D, Meisenzahl E, Scheuerecker J, Schoepf V, Whitty P, Chaney A, et al. Neural correlates of treatment outcome in major depression. Int J Neuropsychopharmacol. 2011;14(4):521-34.
Nugent AC, Diazgranados N, Carlson PJ, Ibrahim L, Lucken-baugh DA, Brutsche N, et al. Neural correlates of rapid anti-depressant response to ketamine in bipolar disorder. Bipolar Disorders. 2014;16(2):119-28.
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