Abstract
Introduction: Porencephaly, as a rare imaging finding, occurs mostly in pediatric patients, causing seizures, motor and behavioral deficits. In some exceptional cases, it is an asymptomatic entity affecting other age groups.
Case presentation: 79-year-old patient with a history of arterial hypertension, who was admitted in the context of a de novo ictal crisis, associated with severe hyponatremia that was corrected and an incidental finding of porencephaly by computed tomography (CT). For the evidence of structural brain damage and the recurrence of the seizure during hospitalization, it was considered a remote symptomatic seizure and, given the high risk of new seizures, anticonvulsant treatment was initiated with a satisfactory evolution until discharge.
Results: At the home visit, the patient was found to be independent to carry out activities of daily living and without recurrence of seizure events, despite discontinuation of anticonvulsant therapy.
Discussion: In this case, the finding of porencephaly was incidental, at an advanced age and with the simultaneous presentation of severe hyponatremia, which could be the cause of the ictal crisis and neurological deficit, without ruling out a remote crisis due to structural alteration.
Conclusions: Porencephaly is difficult to diagnose due to its low frequency and atypical characteristics, as in the case presented. Therefore, the registration and follow-up of cases of porencephaly, both prenatal and postnatal, should be promoted, taking into account the possible differential diagnoses, to facilitate detection and timely medical treatment.
References
Sisa Alvarez ME, Aljure Reales VJ, Suárez Daza F, Sánchez SC, Sierra DS, Vega Quzada JC. Porencefalia, reporte de caso. Arch Med. 2018;18(1):208-14. https://doi.org/10.30554/archmed.18.1.2497.2018
Santra G. Porencephaly may Present even in Elderly. J Assoc Physicians India. 2023;71(5):11-12.
Anonymous Contributors. Porencefalia. Neurocirugía Contemporánea. 2019;22:27. CEST. https://neurocirugiacontemporanea.es/wiki/doku.php?id=porencefalia&s[]=porencefalia
Verbeek E, Meuwissen MEC, Verheijen FW, Govaert PP, Licht DJ, Kuo DS, et al. COL4A2 mutation associated with familial porencephaly and small-vessel disease. Eur J Hum Genet. 2012;20(8):844-51. https://doi.org/10.1038/ejhg.2012.20
Hino-Fukuyo N, Togashi N, Takahashi R, Saito J, Inui T, Endo W, et al. Neuroepidemiology of porencephaly, schizencephaly, and hydranencephaly in Miyagi prefecture, Japan. Pediatr Neurol. 2016;54:39-42.e1. https://doi.org/10.1016/j.pediatrneurol.2015.08.016
Yoneda Y, Haginoya K, Kato M, Osaka H, Yokochi K, Arai H, et al. Phenotypic spectrum of COL4A1 mutations: porencephaly to schizencephaly. Ann Neurol. 2013;73(1):48-57. https://doi.org/10.1002/ana.23736
Ledezma Perdomo MA, Jovel López LE, Alvarenga Thiebaud M. Porencefalia y plasticidad cerebral: a propósito de un caso clínico. Acta Pediátrica Hondureña. 2013;4(1):267-8.
Nakamura Y, Okanishi T, Yamada H, Okazaki T, Hosoda C, Itai T, et al. Progressive cerebral atrophies in three children with COL4A1 mutations. Brain Dev. 2021;43(10):1033-8. https://doi.org/10.1016/j.braindev.2021.06.008
Gavvala JR, Schuele SU. New-Onset seizure in adults and adolescents: a review. JAMA. 2016;316(24):2657-68. https://doi.org/10.1001/jama.2016.18625
Mateos-Aparicio P, Rodríguez-Moreno A. The impact of studying brain plasticity. Front Cell Neurosci. 2019;13:66. https://doi.org/10.3389/fncel.2019.00066
By the 2023 American Geriatrics Society Beers Criteria® Update Expert Panel. American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2023;71(7):2052-81. http://dx.doi.org/10.1111/jgs.18372

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