Abstract
Known since antiquity acetyl salicylic acid (ASA), was first used as an analgesic and in recent times as antiplatelet medication. Its prescription in acute ischaemic stroke and in cerebrovascular disease prevention relyes on random- ized studies with placebo control and meta-analysis. Its use in combination with other antiplatelet drugs has been tested in large multicenter randomized trials controlled with standard medication.
Today ASA prescription in acute ischemic stroke should be started as soon as the patient can swallow the medicine. In secondary prevention of non-cardioembolic stroke its adequate prescription (100-325 mg / day) is an element of good medical practice. In patients with chronic atrial fibrillation that can not be anticoagulated for established contraindications, alone or in combination with clopidogrel is a less safe but usefu. Its combination with controlled- release dipyridamole, is another alternative in secondary prevention.
The aspirin resistance requires exclusion of treatment failure and does not seem to be a common finding in the general population.
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