El déficit cognoscitivo mínimo como manifestación temprana de demencia
PDF

Palabras clave

Trastornos del Conocimiento (Transtornos cognitivos)
Demencia
Enfermedad de Alzheimer,
Pruebas Neuropsicológicas

Resumen

Este artículo presenta una revisión extensa de los antecedentes, las definiciones, la patología y las manifestacio- nes clínicas del deterioro cognoscitivo y de su posible evolución hacia la demencia. También analiza las pruebas necesarias para el diagnóstico oportuno y preciso del deterioro cognoscitivo y su diferenciación con la demencia.
Para terminar hace un análisis de las intervenciones terapéuticas farmacológicas y no farmacológicas, tanto en las fases iniciales del deterioro cognoscitivo como de la demencia, resaltando siempre su impacto en la calidad del paciente, su familia y su entorno social.


PDF

Citas

PETERSEN RC, SMITH GE, WARING SC, ET AL. Aging, memory, and mild cognitive impairment. Int Psychogeriatr 1997; 9:65–9.

PORTET F, OUSSET PJ, VISSER PJ, ET AL. Mild cognitive impairment (MCI) in medical practice: a critical review of the concept and new diagnostic procedure. Report of the MCI Working Group of the European Consortium on Alzheimer’s Disease. J Neurol Neurosurg Psychiatry 2006; 77;714-718.

GAUTHIER S, REISBERG B, ZAUDIG M, ET AL. Mild cognitive impairment. Lancet 2006; 367: 1262–70.

PETERSEN RC. Mild cognitive impairment. Con- tinuum Lifelong Learning. Neurol 2007;13:15–38.

VOISIN T, TOUCHON J, VELLAS B. Mild cog- nitive impairment: a nosological entity? Curr Opin Neurol 2003;16: Suppl 2:S43-5.

BENNETT DA. Mild cognitive impairment. Clin Geiatr Med 2004; 20: 15– 25.

MORRIS JC. Mild cognitive impairment is early stage Alzheimer disease: time to revise diagnostic cri- teria. Arch Neurol 2006;63:15-6.

TUOKKO H, ZARIT SH. Mild cognitive impair- ment. Aging Ment Health 2003;7:235-7.

PETERSEN RC, SMITH GE, WARING, SC, ET AL. Mild cognitive impairment: clinical characteriza- tion and outcome. Arch Neurol 1999; 56:303-308.

BISCHKOPF J, BUSSE A, ANGERMEYER, MC. Mild cognitive impairment--a review of preva- lence, incidence and outcome according to current approaches. Acta Psychiatr Scand 2002; 106: 403-414.

VOISIN T, TOUCHON J, VELLAS B. Mild cog- nitive impairment: a nosological entity?. Curr Opin Neurol 2003; 16 Suppl 2:S43-5.

MANLY JJ, BELL-MCGINTY S, TANG MX, SCHUPF N, STERN Y, MAYEUX R. Implementing diagnostic criteria and estimating frequency of mild cognitive impairment in an urban community. Arch Neurol 2005; 62:1739-46.

PETERSEN RC, STEVENS JC, GANGULI M, ET AL. Practice parameter: early detection of demen- tia: Mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcom- mittee of the American Academy of Neurology. Neurology 2001; 56:1133-1142.

BURNS A, ZAUDIG M. Mild cognitive impair- ment in older people. Lancet 2002; 360:1963-5.

RITCHIE K, ARTERO, S, TOUCHON, J. Clas- sification criteria for mild cognitive impairment: A population-based validation study. Neurology 2001; 56: 37-42.

FISK JD, MERRY, HR, ROCKWOOD K. Varia- tions in case definition affect prevalence but not out- comes of mild cognitive impairment. Neurology 2003; 61: 1179-84.

WINBLAD, B, PALMER, K, KIPIVELTO M, JELIC V, FRATIGLIONI L, WAHLUND LO, ET AL. Mild cognitive impairment: Beyond controver- sies, towards a consensus-report of the international Working Group on Mild Cognitive Impairment. Jour- nal of Internal Medicine 2004: 256, 240–246.

GANGULI M, DODGE HH, SHEN C, ET AL. Mild cognitive impairment, amnestic type: An epide- miologic study. Neurology 2004; 63:115-121.

MORRIS JC, STORANDT M, MILLER JP, ET AL. Mild cognitive impairment represents early-stage Alzheimer’s disease. Arch Neurol 2001; 58:397-405.

MEYER JS, XU G, THORNBY J, CHOWDHURY MH, QUACH M. Is mild cognitive impairment pro- dromal for vascular dementia like Alzheimer’s dis- ease? Stroke 2002; 33:1981-5.

ROMAN GC, SACHDEV P, ROYALL DR, ET AL. Vascular cognitive disorder: a new diagnostic cat- egory updating vascular cognitive impairment and vascular dementia. J Neurol Sci 2004;226:81-7.

BOYLE PA, WILSON RS, AGGARWAL NT, ET AL. Parkinsonian signs in subjects with mild cognitive impairment. Neurology 2005; 65:1901-6.

LOUIS ED, SCHUPF N, MANLY J, MARDER K, TANG MX, MAYEUX R. Association between mild parkinsonian signs and mild cognitive impairment in a community.Neurology 2005; 12; 64:1157-61.

BOZOKI A, GIORDANI B, HEIDEBRINK JL, ET AL. Mild cognitive impairments predict dementia in nondemented elderly patients with memory loss. Arch Neurol 2001; 58:411-6.

LOPEZ OL, BECKER JT, JAGUST WJ, ET AL. Neuropsychological characteristics of mild cognitive impairment subgroups. J Neurol Neurosurg Psychiatry 2006;77:159-65.

DECARLI C. Mild cognitive impairment: preva- lence, prognosis, aetiology, and treatment. Lancet Neurol 2003; 2:15-21.

NORDLUND A, ROLSTAD S, HELLSTROM P, ET AL. The Goteborg MCI study: mild cognitive impairment is a heterogeneous condition. J Neurol Neurosurg Psychiatry 2005; 76:1485.

ELIAS MF, BEISER A, WOLF PA, AU R, WHITE RF, D’AGOSTINO RB. The preclinical phase of alzheimer disease: A 22-year prospective study of the Framingham Cohort. Arch Neurol 2000; 57:808-13.

KAUFER DI, WILLIAMS CS, BRAATEN AJ, GILL K, ZIMMERMAN S, SLOANE PD. Cognitive screening for dementia and mild cognitive impair- ment in assisted living: comparison of 3 tests. J Am Med Dir Assoc 2008; 9:586-93.

SCHINKA JA, RAJ A, LOEWENSTEIN DA, SMALL BJ, DUARA2 R, POTTER H. The cognitive change checklist (3CL): cross-validation of a measure of change in everyday cognition. Int J Geriatr Psychia- try 2009 Jul 2. [Epub ahead of print]

LONIE JA, TIERNEY KM, EBMEIER KP. Screening for mild cognitive impairment: a systematic review. Int J Geriatr Psychiatry 2009; 24:902-15.

DECARLI C, MUNGAS D, HARVEY, D, ET AL. Memory impairment, but not cerebrovascular dis- ease, predicts progression of MCI to dementia. Neu- rology 2004; 63:220-27.

COREY-BLOOM J. The ABC of Alzheimer’s disease: cognitive changes and their management in Alzheimer’s disease and related dementias. Int Psycho- geriatr 2002; 14:51-75.

FÖRSTL H, BICKEL H, FRÖLICH L Y COLS. Mild cognitive impairment with predictors of rapid decline. Dtsch Med Wochenschr 2008; 133:431-6.

FÖRSTL H, BICKEL H, FRÖLICH L Y COLS. MCI-plus: mild cognitive impairment with rapid pro- gression. Part I: prevention and therapy. Dtsch Med Wochenschr 2009; 134:39-44.

FÖRSTL H, BICKEL H, FRÖLICH L Y COLS. MCI-plus: mild cognitive impairment with rapid progression. Part II: Biomarkers and research methods.

Dtsch Med Wochenschr 2009; 134:88-91.

MANES F, SERRANO C, CALCAGNO ML, CAR- DOZO J, HODGES J. Accelerated forgetting in sub- jects with memory complaints. A new form of Mild Cognitive Impairment? J Neurol 2008; 255:1067-70.

CROOK TH, BARTUS RT, FERRIS SH, ET AL. Age-associated memory impairment: proposed diag- nostic creiteria measures clinical change report of a National Institute of Mental Health Work Group. Developmental Neuropsychology 1986; 2:261-230.

LEVY R. Aging-associated cognitive decline. Working Party of the International Psychogeriatric Association in collaboration with the World Health Organization. Int Psychogeriatr 1994; 6:63-8.

RITCHIE K, TOUCHON J. Mild cognitive impairment: Conceptual basis and current nosologi- cal status. Lancet 2000; 355:225-8.

SMALL BJ, MOBLY JL, LAUKKA EJ ET AL. Cog- nitive deficits in preclinical Alzheimer’s disease. Acta Neurol Scand Suppl 2003; 179:29-33.

JELIC V, KIVIPELTO M, WINBLAD B. Clinical trials in mild cognitive impairment: lessons for the future. J Neurol Neurosurg Psychiatry 2006; 77:429-38.

LARRIEU S, LETENNEUR L, ORGOGOZO JM, ET AL. Incidence and outcome of mild cogni- tive impairment in a population-based prospective cohort. Neurology 2002; 59:1594-9.

GRAHAM JE, ROCKWOOD K, BEATTIE BL, ET AL. Prevalence and severity of cognitive impairment with and without dementia in an elderly population. Lancet 1997; 349:1793-6.

LOPEZ OL, JAGUST WJ, DEKOSKY, ST, ET AL. Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cog- nition Study: part 1. Arch Neurol 2003; 60:1385.

NESTOR PJ, SCHELTENS P, HODGES, JR. Advances in the early detection of Alzheimer’s dis- ease. Nat Med 2004; 10 Suppl:S34-41.

DECARLI C, MILLER BL, SWAN GE, ET AL. Cerebrovascular and brain morphologic correlates of mild cognitive impairment in the National Heart, Lung, and Blood Institute Twin Study. Arch Neurol 2001; 58:643-7.

BENNETT DA, WILSON RS, SCHNEIDER JA, ET AL. Natural history of mild cognitive impairment in older persons. Neurology 2002; 59:198-205.

PETERSEN RC. Mild cognitive impairment as a diagnostic entity. J Intern Med 2004; 256:183-94.

PALMER K, WANG HX, BACKMAN L, ET AL. Differential evolution of cognitive impairment in non- demented older persons: results from the Kungshol- men Project. Am J Psychiatry 2002; 159:436-42.

WAHLUND LO, PIHLSTRAND E, JONHAGEN ME. Mild cognitive impairment: Experience from a memory clinic. Acta Neurol Scand Suppl 2003; 179:21-

PETERSEN RC, THOMAS RG, GRUNDMAN M, ET AL. Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med 2005; 352:2379-88.

MITCHELL AJ, SHIRI-FESHKI M. Temporal trend in the long term risk of progression of mild cognitive impairment: a pooled analysis. J Neurol Neu- rosurg Psychiatry. 2008;79:1386-91.

STORANDT M, GRANT EA, MILLER JP, MORRIS JC. Rates of progression in mild cognitive impairment and early Alzheimer’s disease. Neurology 2002; 59:1034-41.

STOKHOLM J, JAKOBSEN O, CZARNA JM, ET AL. Years of severe and isolated amnesia can pre- cede the development of dementia in early-onset Alzheimer’s disease. Neurocase 2005; 11:48-55.

AMIEVA H, LETENNEUR L, DARTIGUES JF, ET AL. Annual rate and predictors of conversion to dementia in subjects presenting mild cognitive impairment criteria defined according to a popu- lation-based study. Dement Geriatr Cogn Disord 2004; 18:87-93.

BUERGER K, TEIPEL SJ, ZINKOWSKI R, ET AL. CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects. Neurology 2002; 59:627-9.

AMIEVA H, JACQMIN-GADDA H, ORGOGOZO JM, ET AL. The 9 year cognitive decline before dementia of the Alzheimer type: a prospective popu- lation-based study. Brain 2005; 128:1093-1101.

TOUCHON J, RITCHIE K. Prodromal cognitive disorder in Alzheimer’s disease. Int J Geriatr Psychiatry 1999; 14:556-63.

SACUIU S, SJOGREN M, JOHANSSON B, ET AL. Prodromal cognitive signs of dementia in 85-year-olds using four sources of information. Neu- rology 2005; 65:1894-1900.

BARBEAU E, DIDIC M, TRAMONI E, ET AL. Evaluation of visual recognition memory in MCI patients. Neurology 2004; 62:1317-22.

AGGARWAL NT, WILSON RS, BECK TL, ET AL. Mild cognitive impairment in different functional domains and incident Alzheimer’s disease. J Neurol Neurosurg Psychiatry 2005; 76:1479-84.

TIERNEY MC, YAO C, KISS A, MCDOWELL I. Neuropsychological tests accurately predict incident Alzheimer disease after 5 and 10 years. Neurology 2005; 64:1853-9.

CHEN P, RATCLIFF G, BELLE SH, ET AL. Cog- nitive tests that best discriminate between presymp- tomatic AD and those who remain nondemented. Neurology 2000; 55:1847-53.

LEVY R. Aging-associated cognitive decline Working Party of the International Psychogeriatric Association in collaboration with the World Health Organization. Int Psychogeriatr 1994; 6:63-8.

FLEISHER AS, SOWELL BB, TAYLOR C, GAMST AC, PETERSEN RC, THAL LJ; Alzheimer’s Disease Cooperative Study. Clinical predictors of progression to Alzheimer disease in amnestic mild cognitive impairment.Neurology 2007; 68:1588-95.

FARLOW MR, HE Y, TEKIN S, ET AL. Impact of APOE in mild cognitive impairment. Neurology 2004; 63:1898-1901.

PETERSEN RC, SMITH GE, IVNIK RJ, ET AL. Apolipoprotein E status as a predictor of the devel- opment of Alzheimer’s disease in memory-impaired individuals. JAMA 1995; 273:1274-8.

AGGARWAL NT, WILSON RS, BECK TL, ET AL. The apolipoprotein E epsilon4 allele and incident Alzheimer’s disease in persons with mild cognitive impairment. Neurocase 2005; 11:3-7.

TSCHANZ JT, WELSH-BOHMER KA, LYKET- SOS CG, ET AL. Conversion to dementia from mild cognitive disorder. The Cache County Study. Neurol- ogy 2006;67:229–234.

BUERGER K, EWERS M, ANDREASEN N, ET AL. Phosphorylated tau predicts rate of cognitive decline in MCI subjects: a comparative CSF study. Neurology 2005; 65:1502-3.

DEVANAND DP, PELTON GH, ZAMORA D, ET AL. Predictive utility of apolipoprotein E genotype for Alzheimer disease in outpatients with mild cogni- tive impairment. Arch Neurol 2005; 62:975-80.

MARUYAMA M, MATSUI T, TANJI H, ET AL. Cerebrospinal fluid tau protein and periventricular white matter lesions in patients with mild cognitive impairment: Implications for 2 major pathways. Arch Neurol 2004; 61:716-20.

MARUYAMA M, HIGUCHI M, TAKAKI Y, ET AL. Cerebrospinal fluid neprilysin is reduced in pro- dromal Alzheimer’s disease. Ann Neurol 2005; 57:832- 842.

SKOOG I, DAVIDSSON P, AEVARSSON O, ET AL. Cerebrospinal fluid beta-amyloid 42 is reduced before the onset of sporadic dementia: a population- based study in 85-year-olds. Dement Geriatr Cogn Disord 2003; 15:169-76.

KILLIANY RJ, GOMEZ-ISLA T, MOSS M, ET AL. Use of structural magnetic resonance imaging to predict who will get Alzheimer’s disease. Ann Neurol 2000; 47:430-9.

FOX NC, CRUM WR, SCAHILL RI, ET AL. Imag- ing of onset and progression of Alzheimer’s disease with voxel-compression mapping of serial magnetic resonance images. Lancet 2001; 358:201-5.

KORF ES, WAHLUND LO, VISSER PJ, SCHEL- TENS P. Medial temporal lobe atrophy on MRI predicts dementia in patients with mild cognitive impairment. Neurology 2004; 63:94-100.

JACK CR JR, SHIUNG MM, WEIGAND SD, ET AL. Brain atrophy rates predict subsequent clinical conversion in normal elderly and amnestic MCI. Neu- rology 2005; 65:1227-31.

STOUB TR, BULGAKOVA M, LEURGANS S, ET AL. MRI predictors of risk of incident Alzheimer disease: a longitudinal study. Neurology 2005; 64:1520- 24.

BELL-MCGINTY S, LOPEZ OL, MELTZER CC, ET AL. Differential cortical atrophy in subgroups of mild cognitive impairment. Arch Neurol 2005; 62:1393-7.

MUNGAS D, HARVEY D, REED BR, ET AL. Longitudinal volumetric MRI change and rate of cognitive decline. Neurology 2005; 65:565-71.

BECKER JT, DAVIS BA, HAYASHI KM, ET AL. Three-dimensional Patterns of Hippocampal Atrophy in Mild Cognitive Impairment. Arch Neurol 2006;63:97-101.

KANTARCI K, PETERSEN RC, BOEVE BF, ET AL. DWI predicts future progression to Alzheimer disease in amnestic mild cognitive impairment. Neu- rology 2005; 64:902-4.

CHETELAT G, DESGRANGES B, DE LA SAY- ETTE V, ET AL. Mild cognitive impairment: Can FDG-PET predict who is to rapidly convert to Alzheimer’s disease?. Neurology 2003; 60:1374.

MOSCONI L, PERANI D, SORBI S, ET AL. MCI conversion to dementia and the APOE genotype: A prediction study with FDG-PET. Neurology 2004; 63:2332-40.

ANCHISI D, BORRONI B, FRANCESCHI M, ET AL. Heterogeneity of brain glucose metabolism in mild cognitive impairment and clinical progression to Alzheimer disease. Arch Neurol 2005; 62:1728-33.

KLUNK WE, ENGLER H, NORDBERG A, ET AL. Imaging brain amyloid in Alzheimer’s disease with Pittsburgh Compound-B. Annals of Neurology 2004; 55: 306-19.

WOLK DA, PRICE JC, SAXTON JA, ET AL. Amy- loid imaging in mild cognitive impairment subtypes. Ann Neurol 2009;65:557-68.

CLARKE R, SMITH AD, JOBST KA, ET AL. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol 1998;55: 1449-55.

SESHADRI S, BEISER A, SELHUB J, ET AL. Plasma homocysteine as a risk factor for dementia and Alzheimer’s disease. N Engl J Med 2002; 346:476-83.

PRINS ND, DEN HEIJER T, HOFMAN A, ET AL. Homocysteine and cognitive function in the elderly: the Rotterdam Scan Study. Neurology 2002;59: 1375-80.

DEN HEIJER T, VERMEER S, CLARKE R, ET AL. Homocysteine and brain atrophy on MRI of non-demented elderly. Brain 2003; 126: 170-5.

MCMAHON JA, GREEN TJ, SKEAFF CM, ET AL. A controlled trial of homocysteine lowering and cognitive performance. N Engl J Med 2006;354: 2764- 72.

MORRIS MC, EVANS DA, TANGNEY CC, BIE- NIAS JL, WILSON RS. Associations of vegetable and fruit consumption with age-related cognitive change. Neurology 2006; 67:1370–1376.

CHAN DC, KASPER JD, BLACK BS, RABINS PV. Prevalence and correlates of behavioral and psychiatric symptoms in community-dwelling elders with dementia or mild cognitive impairment: the Memory and Medical Care Study. Int J Geriatr Psychia- try 2003;18:174–182.

BARNES DE, ALEXOPOULOS GS, LOPEZ OL, WILLIAMSON JD, YAFFE K. Depressive symptoms, vascular disease, and mild cognitive impairment: find- ings from the cardiovascular health study. Arch Gen Psychiatry 2006;63:273–279.

CUMMINGS JL. Behavioral and neuropsychiatric outcomes in Alzheimer’s disease. CNS Spectr. 2005; 10(11 Suppl 18): 22-5.

ABIZANDA P, LÓPEZ-JIMÉNEZ E, LÓPEZ- RAMOS B Y COLS. Síntomas neuropsiquiátricos en deficit cognoscitivo leve y enfermedad de Alzheimer disease. Rev Esp Geriatr Gerontol 2009.100. EDWARDS ER, SPIRA AP, BARNES DE, YAFFE

K. Neuropsychiatric symptoms in mild cognitive impairment: differences by subtype and progression to dementia. Int J Geriatr Psychiatry 2009; 24:716-22.

LEE HB, LYKETSOS CG. Depression in Alzheimer’s disease: heterogeneity and related issues. Biol Psychiatry 2003;54:353-362.

MODREGO PJ, FERRANDEZ J. Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type: a prospective cohort study. Arch Neurol 2004;61:1290– 1293.

PALMER K, BERGER AK, MONASTERO R, WINBLAD B, BÄCKMAN L, FRATIGLIONI

L. Predictors of progression from mild cognitive impairment to Alzheimer disease. Neurology 2007; 68:1596-602.

PETERSEN RC. Conversion. Neurology 2006 14;

(9 Suppl 3):S12-3.

BENNETT DA, SCHNEIDER JA, BIENIAS JL, ET AL. Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions. Neurology 2005; 64:834-41.

PETERSEN RC, DOODY R, KURZ A, ET AL. Current concepts in mild cognitive impairment. Arch Neurol 2001; 58:1985-92.

MARKESBERY W, SCHMITT F, KRYSCIO R ET AL. Neuropathologic Substrate of Mild Cognitive Impairment Arch Neurol. 2006;63: 38-46.

TABERT, MH, ALBERT, SM, BORUKHOVA- MILOV, L, ET AL. Functional deficits in patients with mild cognitive impairment: prediction of AD. Neurol- ogy 2002; 58:758-64.

FELDMAN H, SCHELTENS P, SCARPINI E, ET AL. Behavioral symptoms in mild cognitive impairment. Neurology 2004; 62:1199-1201.

LOPEZ OL, BECKER JT, SWEET RA. Non- cognitive symptoms in mild cognitive impairment subjects. Neurocase 2005; 11:65-71.

LYKETSOS CG, LOPEZ O, JONES B, ET AL. Prevalence of neuropsychiatric symptoms in demen- tia and mild cognitive impairment: results from the cardiovascular health study. JAMA 2002; 288:1475- 83.

VINKERS DJ, GUSSEKLOO J, STEK ML, ET AL. Temporal relation between depression and cog- nitive impairment in old age: prospective population based study. BMJ 2004; 329:881.

VISSER PJ, SCHELTENS P, VERHEY FR. Do MCI criteria in drug trials accurately identify subjects with predementia Alzheimer’s disease? J Neurol Neu- rosurg Psychiatry 2005; 76:1348-54.

Deppressive disorders. Diagnostic and statistical manual of mental disorders Washington, DC: Ameri- can Psychiatric Association; 1994.

MANNING C. Beyond memory: neuropsycho- logic features in differential diagnosis of dementia. Clin Geriatr Med 2004; 20:45-58.

SALLOWAY S, FERRIS S, KLUGER A, ET AL. Efficacy of donepezil in mild cognitive impairment: a randomized placebo-controlled trial. Neurology 2004; 63:651-7.

MAYOR S. Regulatory authorities review use of galantamine in mild cognitive impairment. BMJ 2005; 330:276.

HERNÁNDEZ L, MONTAÑÉS P, GÁMEZ A, CANO C, NÚÑEZ E. Neuropsicología del envejeci- miento normal. Rev Asoc Colomb Gerontol Geriatr 2007; 21: 992-1004.

Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.

Descargas

Los datos de descargas todavía no están disponibles.