Abstract
OBJECTIVE: to describe the behavior of seizures in a group of epileptic menopausic women.
METHODOLOGY: a descriptive observational study was made during four months to include women with epilepsy ages 45 and older who attended a neurologic evaluation and had epilepsy diagnosed. Data related to the type of crisis (Kyoto), type of epilepsy (Hamburg), were obtained; date of last menses to establish the moment of the menopause, history of catamenial epilepsy, use of anticonvulsants and information corresponding to images MRI or CT-SCAN and EEG was also gathered
RESULTS: in our study we found that the average of age for the beginning of the menopause was equal for those who had the epilepsy before it (50.2 years) and those for whom the epilepsy had a later beginning (49.8 years).
CONCLUSIONS: the medical literature suggests that the age at natural menopause in women with epilepsy is lower than might be expected from statistics for the general population. Our data did not support this hypothesis.
References
Lee MA. Epilepsy in the menopause. Neurology 1999; 53(Suppl 1): S41.
Klein P, Herzog AG. Hormonal effects on epilepsy in women. Epilepsia 1998; 39 (Suppl.8): S9-S16.
Harden CL, Pulver MC, Jacobs AR. The effect of menopause and perimenopause on the course of epilepsy.
Epilepsia 1997; 39 (suppl.8): 133-134.
Rozniecka-Rosciszewska D. Clinical course of epilepsy in women as a function of puberty, maturity and climacterium. Neurol Neurochir Pol 1975; 9: 217-222.
Morrell MJ. Hormones and epilepsy through the lifetime. Epilepsia 1992; 33(suppl.4): S49-61.
Herzog AG. Reproductive endocrine considerations and hormonal therapy for women with epilepsy. Epilepsia 1992; 32(suppl.6): 527-533.
Morrell MJ, Sperling MR, Stecker M, Dichter MA. Sexual dysfunction in partial epilepsy: a deficit in physiologic sexual arousal. Neurology 1994; 44: 243-247.
Morrell MJ. Epilepsy in women. Ame Fam Physician 2002; 66: 1489-1494.
Drislane FW, Coleman AE, Schomer DL, Ives J, Levesque LA, Seibel MM, Herzog AG. Altered pulsatilite secretion of luteinizing hormone in women with epilepsy. Neurology 1994; 44: 306-310.
Herzog AG, Seibel MM, Schomer DL, Vaitukaitis JL, Geschwind N. Reproductive endocrine disorders in women with partial seizures of temporal lobe origin. Arch Neurol 1986; 43: 341-346.
Herzog AG. A hypothesis to integrate partial seizures of temporal lobe origin and reproductive endocrine disorders. Epilepsy Res 1989; 3: 151-159.
Bauer J. Interactions between hormones and epilepsy in female patients. Epilepsia 2001; 42: 20-22.
Bauer J, Burr W, Elger CE. Seizure occurrence during ovulatory and anovulatory cycles in patients with temporal lobe epilepsy: a prospective study. Eur J Neurol 1998; 5: 83-88.
Cummings LN, Giudice L, Morrell Mj. Ovulatory function in epilepsy. Epilepsia 1995; 36: 353-357.
Comission on clasification and terminology of the International League against Epilepsy. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia 1981; 22: 489-501.
Comission on clasification and terminology of the International League against Epilepsy Proposal for revised classification of epilepsies and epileptic syndromes. Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia 1989; 30: 389-399.
Klein P, Serje A, Pezzullo JC. Premature ovarian failure in women with epilepsy. Epilepsia 2001; 42: 1584-1589.
Harden CL, Koppel BS, Herzog AG, Nikolov BG, Hauser WA. Seizure frequency is associated with age at menopause in women with epilepsy. Neurology 2003; 61: 451-455.
Harden Cl, Pulver MC, Ravdin L, Jacobs AR. The effect of menopause and perimenopause on the course of epilepsy. Epilepsia 1999; 40: 1402-1407.
Abbasi F, Krumholz A, Kittner SJ, Langerberg P. Effects of menopause on seizures in women with epilepsy.
Epilepsia 1999; 40: 205-210.
Rattya J, Pakarinen AJ, Knip M, Repo-Outakoski M, Myllyla VV, Isojarvi JI. Early hormonal changes during valproate or carbamazepine treatment: a 3 month study. Neurology 2001; 57: 440-444.
Martínez-Ferri M. Atención integrada a la mujer epiléptica. Rev Neurol 2002; 34: 471-476.
Cooper GS, Sandler DP. Age at natural menopause and mortality. Ann Epidemiol 1998; 8: 229-235.
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