Resumen
La migraña es una enfermedad neurobiológica. Diversas estructuras cerebrales participan en el procesamiento del dolor, con la presencia de fenómenos neuronales y bioquímicos que modulan la respuesta del sistema nervioso. A través de los estudios realizados se puede observar la presencia de diferentes elementos que participan en la generación de la migraña; estos pueden ser estructurales (alteración de sustancia gris periacueductal y núcleos del rafé), genéticos, neuronales como la depresión cortical diseminada y la liberación de múltiples neurotransmisores entre los que predominan el péptido relacionado con el gen de la calcitonina y la serotonina, que median diferentes tipos de alteraciones durante el proceso de inflamación neurogénica, y cambios en funcionamiento de múltiples áreas como sistema nervioso autónomo entre otras.
Citas
FERRARI MD, DICHGANS M. Genetics of Primary Headache. In Wolff's Headache and Other Head Pain. Silberstein S, Lipton RB, Dodick DW eds. 8TH Ed. New York: Oxford University Press 2008; Chapter 9: 133-149.
HOLLAND P, GOADSBY PJ. The hypothalamic orexinergic system: Pain and Primary Headaches. Headache-Current Headache 2007: 951-962.
CHAKRAVARTY A, SEN A. Migraine, neuropathic pain and nociceptive pain: Towards a unifying concept. Medical Hypothesis. 2010; 74: 225-231.
GEPPETTI P, ROSSI E, CHIARUGI A, BENEMEI S. Antidromic vasodilation and the migraine mechanism. J Headache Pain 2012; 13: 103-111.
JOHNSON KW, BOLAY H. Neurogenic inflammatory mechanisms. In Olesen J, Goadsby PJ, Ramadan NM, Tfelt-Hansen P, Welch KWA eds. The Headaches, 3rd Ed. Philadelphia: Lippincott-Williams and Wilkins. 2006; Chapter 33: 309-319.
OLESEN J, BURSTEIN R, ASHINA M, TFELT-HANSEN P. Origin of pain in migraine: Evidence of peripheral sensitization. Lancet Neurol 2009; 9: 679-690.
WEILLER C, MAY A, LIMMROTH V, JÜPTNER M, KAUBE H, SCHAYCK RV, COENEN HH, DIENER HC. Brain stem activation in spontaneous migraine attacks. Nat Med 1995; 1: 658-660.
AFRIDI SK, GIFFIN NJ, KAUBE H, FRISTON KJ, WARD NS, FRACKOWIAK RS, GOADSBY PJ. A PET study in spontaneous migraine. Arch Neurol 2005; 62: 1270-1275.
GUPTA S, NAHAS SJ, PETERLIN L. Chemical mediators of migraine: Preclinical and clinical observations. Headache 2011; Headache Currents: 1029-1045.
WAEBER C. Serotonin and other biogenic Amines. En Olesen J, Goadsby PJ, Ramadan NM, Tfelt-Hansen P, Welch KWA eds. The Headaches, 3rd Ed. Philadelphia: Lippincott-Williams and Wilkins. 2006; Chapter 14: 143-149.
HAMEL E. Serotonin and migraine: Biology and Clinical implications. Cephalalgia-Headache Currents. 2007; 27: 1295-1300.
BRAIN S, EDVINSSON L. Calcitonin Generelated peptide and other peptides. In Olesen J, Goadsby PJ, Ramadan NM, Tfelt-Hansen P, Welch KWA eds. The Headaches, 3rd ED. Philadelphia: Lippincott-Williams and Wilkins. 2006; Chapter 16: 159-164.
HAMEL E, SAXENA PR. 5-Hydroxytrptamine involvement in migraine. In Olesen J, Goadsby PJ, Ramadan NM, Tfelt-Hansen P, Welch KWA eds. The Headaches, 3rd Ed. Philadelphia: Lippincott-Williams and Wilkins. 2006; Chapter 29: 275-280.
IVERSEN HU, REUTER U. Nitric oxide involvement in migraines. In Olesen J, Goadsby PJ, Ramadan NM, Tfelt-Hansen P, Welch KWA eds. The Headaches, 3rd Ed. Philadelphia: Lippincott-Williams, and Wilkins. 2006; Chapter 30: 281-287.
GOADSBY PJ, OSHINSKY ML. Pathophysiology of Headache. In Wolff's Hedadache and Other Head Pain. Silberstein S, Lipton RB, Dodick DW eds. 8Th Edition. New York: Oxford University Press. 2008; 7: 105-119
MAIZELS M, AURORA S, HEINRICHER M. Beyond neurovascular: Migraine as dysfunctional neurolimbic pain network. Headache 2012; 52: 1553-1565.
Stuart S, Cox HC, Lea RA, Griffiths LR. The role of the MTHFR gene in migraine. Hedadache Currents 2012; 52: 515-520.
ZHANG X, LEVY D, KAINZ V, NOSEDA R, JAKUBOWSKI M, BURSTEIN R. Activation of central trigeminovascular neurons by cortical spreading depression. Ann Neurol 2011; 69: 855-865.
GURSOY-OZDEMIR Y, QIU J, MATSUOKA N, BOLAY H, BERMPOHL D, JIN H, WANG X, ROSENBERG GA, LO EH, MOSKOWITZ MA. Cortical spreading depression activates and upregulates MMP-9. J Clin Invest 2004; 113; 1447-1455.
SANCHEZ DEL RIO, OLESEN J, DIENER HC. Hemodynamics and neuroimaging of migraines. En Olesen J, Goadsby PJ, Ramadan NM, Tfelt-Hansen P, Welch KWA eds. The Headaches, 3rd edition. Philadelphia:Lippincott-Williams and Wilkins. 2006; Chapter 37: 351-362.
MERIKENGAS KR. Update on the genetics of migraine. Headache Currents 2012; 52: 521-522.
LAFRENIÈRE RG, CADER MZ, POULIN JF, ANDRES-ENGUIX I, SIMONEAU M, GUPTA N, ET AL. A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura. Nat Med 2010; 16: 1157-1160.
COLSON NJ, LEA RA, QUINLAN S, GRIFFITHS LR. The role of vascular and hormonal genes in migraine susceptibility. Mol Genet Metab 2006; 88: 107-113.
KOWA H, FUSAYASU E, IJIRI T, ISHIZAKI K, YASUI K, NAKASO K. Association of the insertion/deletion polymorphism of the angiotensiin I-converting enzyme gene in patients with migraine with aura. Neurosci Lett 2005; 374; 129-131.
AVNON Y, NITZAN M, SPRECHER E, ROGOWSKI Z, YARNITSKY D. Different patterns of parasympathetic activation in uni-and bilateral migraineurs. Brain 2003; 126: 1660-1670.
YILDIZ SK, YILDIZ N, KORKMAZ B, ALTUN RENDE B, GEZICI AR, ALKOY S. Sympathetic skin responses from frontal region in migraine headache; A pilot study. Cephalalgia 2008; 28: 696-704.
WOLF ME, JÄGER T, BÄZNER H, HENNERICI M. Changes in functional vasomotor reactivity in migraine with aura. Cephalalgia 2009; 29: 1156-1164.
MULLER M, MARZINIAK M. The linear behavior of the system middle cerebral artery flow velocity and blood pressure in patients with migraine. Lack of autonomic control?. Stroke 2005; 36: 1886-1890.
MONTAGNA P, WELCH KA. Brain Metabolism in migraines. In Olesen J, Goadsby PJ, Ramadan NM, Tfelt-Hansen P, Welch KWA eds. The Headaches 3rd Ed. Philadelphia: Lippincott-Williams and Wilkins. 2006; Chapter 38: 363-367.
OLESEN J, GOADSBY PJ. Synthesis of migraine mechanisms. In Olesen J, Goadsby PJ, Ramadan NM, Tfelt-Hansen P, Welch KWA eds. The Headaches, 3rd edition, Philadelphia: Lippincott-Williams and Wilkins. 2006; Chapter 42: 393-398.
LODER E. What is the evolutionary advantage of migraine? Cephalalgia 2002; 8: 624-632.
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