Current state of multiple sclerosis in Colombia
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Keywords

Colombia
drug costs
economic
epidemiology
multiple sclerosis
prevalence (MeSH)

Abstract

Introduction: Two local epidemiological studies describe Colombia as low risk for multiple sclerosis (MS). New information systems, which allow for a more accurate approximation, are currently available.

Objective: To estimate the national prevalence of MS, as well as by regions, and to analyze national drug costs.

Materials and methods: We obtained data from the Individual Registry of Health care provision (RIPS), with the diagnosis code G35x for multiple sclerosis, taking the confirmed new and repeated diagnoses between 2009 and 2013, by gender, age group and geographical location. For the analysis of medications, we use the database SISMED 2014 searching for all drugs available in Colombia: interferon beta 1A, interferon beta 1B, glatiramer acetate, natalizumab, mitoxantrone and fingolimod.

Results: According to the RIPS, 3,462 patients with diagnosis of MS contacted the health system in Colombia during the period 2009-2013. The national prevalence for the period was 7.52 / 100,000, with the highest figure in Bogota (16.25) with 1213 patients, followed by Quindío (13.03) and Risaralda (11.18). The largest proportion of patients were in the 50 to 54 years age group, and 70% were women. Additionally, in 2014 Colombia spent COP $ 86 billion pesos (43 million US dollars) for MS drugs, around US$12,500 per patient/year.

Conclusion: Colombia is a country with intermediate risk for MS, a disease that implies a high direct cost for the health system.

https://doi.org/10.22379/2422402256%20

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References

SÁNCHEZ JL, AGUIRRE C, ARCOS-BURGOS OM, JIMÉNEZ I, JIMÉNEZ M, LEÓN F, ET AL. Prevalencia de la esclerosis múltiple en Colombia. Rev Neurol. 2000;31:1101-3.

TORO J, SARMIENTO OL, DÍAZ DEL CASTILLO A, SATIZÁBAL CL, RAMÍREZ JD, MONTENEGRO AC, ET AL. Prevalence of multiple sclerosis in Bogotá, Colombia. Neuroepidemiology 2007;28:33-8.

TORO J, CÁRDENAS S, FERNANDO MARTÍNEZ C, URRUTIA J, DÍAZ C. Multiple sclerosis in Colombia and other Latin American Countries. Mult Scler Relat Disord. 2013;2:80-9.

OJEDA E, DÍAZ-CORTÉS D, ROSALES D, DUARTE-REY C, ANAYA JM, ROJAS-VILLARRAGA A. Prevalence and clinical features of multiple sclerosis in Latin America. Clin Neurol Neurosurg. 2013;115:381-7.

ROSATI G. The prevalence of multiple sclerosis in the world: an update. Neurol Sci. 2001;22:117-39.

HINCAPIÉ-ZAPATA ME, SUÁREZ-ESCUDERO JC, PINEDA-TAMAYO R, ANAYA JM. Calidad de vida en esclerosis múltiple y otras enfermedades crónicas autoinmunes y no autoinmunes. Rev Neurol. 2009;48:225-30.

ZARCO LA, MILLÁN SP, LONDOÑO D, PARADA L, TABORDA A, BORDA MG. Costo-efectividad del tratamiento con interferón beta en pacientes con síndrome clínico aislado de alto riesgo en Colombia. Biomédica 2014;34:110-7.

ROJAS O-L, ROJAS-VILLARRAGA A, CRUZ-TAPIAS P, SÁNCHEZ JL, SUÁREZ-ESCUDERO J-C, PATARROYO M-A, ET AL. HLA class II polymorphism in Latin American patients with multiple sclerosis. Autoimmun Rev. 2010;9:407-13.

ROMERO M, ARANGO C, ALVIS N, SUÁREZ JC, DUQUE A. Costos de la esclerosis múltiple en Colombia. Value Health 2011;14:48-50.

ROMANO M, MACHNICKI G, ROJAS JI, FRIDER N, CORREALE J. There is much to be learnt about the costs of multiple sclerosis in Latin America. Arq Neuropsiquiatr. 2013;71:549-55.

VILLA-CAMACHO JC, VARGAS-ZAMBRANO JC, GONZÁLEZ JM. Modelo de detección de anticuerpos neutralizantes contra IFN-? mediante citometría de flujo. Biomédica 2012;32:617-22.

KURTZKE F. A reassessment of the distribution of multiple sclerosis. Part one. Acta Neurol Scand. 1975;51:110-36.

MANOUCHEHRINIA A, TANASESCU R, TENCH CR, CONSTANTINESCU CS. Mortality in multiple sclerosis: meta-analysis of standardised mortality ratios. J Neurol Neurosurg Psychiatry 2015:1-8.

SCALFARI A, KNAPPERTZ V, CUTTER G, GOODIN DS, ASHTON R, EBERS GC. Mortality in patients with multiple sclerosis. Neurology 2013;81:184-92.

MARRIE RA, ELLIOTT L, COSSOY M, BLANCHARD J, LEUNG S, YU N. Effect of comorbidity on mortality in multiple sclerosis. Neurology 2015;85:240-7.

SMESTAD C, SANDVIK L, CELIUS EG. Excess mortality and cause of death in a cohort of Norwegian multiple sclerosis patients. Mult Scler. 2009;15:1263-70.

CUBILLOS L, ALFONSO EA. Análisis descriptivo preliminar de los recobros en el Sistema General de Seguridad Social en Salud 2002 a 2005. Bogotá: Ministerio de la Protección Social; 2005. Disponible en: http://www.minsalud.gov.co/salud/Documents/Analisis%20Descriptivo%20Preliminar%20de%20los%20Recobros.pdf (Última consulta: julio 12 de 2014).

HUBER AK, DUNCKER PC, IRANI DN. The conundrum of interferon-? non-responsiveness in relapsing-remitting multiple sclerosis. Cytokine 2015;74:228-36.

CORREALE J, ABAD P, ALVARENGA R, ALVES-LEÓN S, ARMAS E, BARAHONA J, ET AL. Management of relapsing-remitting multiple sclerosis in Latin America: Practical recommendations for treatment optimization. J Neurol Sci. 2014;339:196-206.

RUIZ-GAVIRIA R, BARACALDO I, CASTAÑEDA C, RUIZ-PATIÑO A, ACOSTA-HERNÁNDEZ A, ROSSELLI D. Specificity and sensitivity of aquaporin 4 antibody detection tests in patients with neuromyelitis optica: a meta-analysis. Mult Scler Relat Disord 4:345-9.

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