Radiological findings of MELAS syndrome in central nervous system (CNS): case report
Vol. 33 No. 1 (2017), Clinical Cases
Vol. 33 No. 1 (2017)

Radiological findings of MELAS syndrome in central nervous system (CNS): case report

Clinical Cases
https://doi.org/10.22379/24224022126
Published 2017-01-01
Oscar Mauricio Romero Osorio
Médico Pontificia Universidad Javeriana. Residente de neurología Pontificia Universidad Javeriana. Bogotá, Colombia.
Ana María Ayala Copete
Estudiante de medicina, Facultad de Medicina, Pontificia Universidad Javeriana. Bogotá, Colombia
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Keywords

MELAS
Magentic resonance
Spectroscopy
CT Scan
Functional MRI (MeSH)

Abstract

A clinical case of a young adult patient with recurrent episodes suggestive of stroke, with typical radiological changes of MELAS disease with genetic confirmation of mutation in A3243G gene.

https://doi.org/10.22379/24224022126

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References

Lorenzoni P, Werneck L, Kay C, Silvado C, Scola R. When should MELAS (Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like episodes) be the diagnosis?. Arq Neuro-Psiquiatr. 2015;73(11):959-967.

Le W, Wang Y Progress in Diagnosing Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episodes. Chinese Medical Journal. 2015;128(13):1820.

Tschampa H, Urbach H, Greschus S, Kunz W, Kornblum C. Neuroimaging characteristics in mitochondrial encepha-lopathies associated with the m.3243A>G MTTL1 mutation. J Neurol. 2012;260(4):1071-1080.

Ito H, Mori K, Kagami S. Neuroimaging of stroke-like episodes in MELAS. Brain Dev. 2011;33(4):283-288.

Ramírez S, Marín J, Hernández J, González A, López O, Posso A, et al. Síndrome de Melas: correlación clínica con hallazgos imagenológicos en espectroscopia y tractografía, reporte de caso. Acta Neurol Colomb. 2016(3);32:227-232.

Kim J, Lim M, Jeon T, Rha J, Eo H, Yoo S, et al. Diffusion and Perfusion Characteristics of MELAS (Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episode) in Thirteen Patients. Korean J Radiol. 2011;12(1):15.

Xie S. MR OEF Imaging in MELAS. Methods in Enzymology. 2014;:433-444.

Weiduschat N, Kaufmann P, Mao X, Engelstad K, Hinton V, DiMauro S, et al. Cerebral metabolic abnormalities in A3243G mitochondrial DNA mutation carriers. Neurology. 2014;82(9):798-805.

Ikawa M, Yoneda M, Muramatsu T, Matsunaga A, Tsuji-kawa T, Yamamoto T, et al. Detection of preclinically latent hyperperfusion due to stroke-like episodes by arterial spin-labeling perfusion MRI in MELAS patients. Mitochondrion. 2013;13(6):676-680.

Tsujikawa T, Yamamoto T, Ikawa M, Yoneda M, Kimura H. Crossed cerebellar hyperperfusion after MELAS attack followed up by whole brain continuous arterial spin labeling perfusion imaging. Acta radiol. 2012;53(2):220-222.

Rodan L, Poublanc J, Fisher J, Sobczyk O, Wong T, Hlasny E, et al. Cerebral hyperperfusion and decreased cerebrovascular reactivity correlate with neurologic disease severity in MELAS. Mitochondrion. 2015;22:66-74.

Wang Z, Xiao J, Xie S, Zhao D, Liu X, Zhang J, et al. MR evaluation of cerebral oxygen metabolism and blood flow in stroke-like episodes of MELAS. J Neurol Sci. 2012;323(1-2):173-177.

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