Abstract
Neurocysticercosis, as part of the Teniasis / Cysticercosis complex, is helminthiasis that more frequently involves the central nervous system, particularly in countries undergoing development where its transmission is endemic; its clinical manifestations are variable, according to its location in the central nervous system, highlighting epilepsy as one of its main forms of clinical presentation. Advances in the use of diagnostic methods immunological tests, as well as neuroimaging and the introduction two years ago of new criteria diagnoses have improved the diagnostic certainty, with the implementation of anti-treatment cestocide associated with the use of corticosteroids and, in some particular cases, the intervention surgical treatment provides not only a therapeutic option but also a better prognosis for patients affected by this condition. The challenge today is focused on implementing measures of public health on the biological cycle of the CTC to achieve its eradication.
References
Organización Panamericana de la Salud (OPS). Pautas operativas para las actividades de control de la teniasis y la cisticercosis causadas por Taenia solium. OPS; 2019.
Garcia HH, Del Brutto OH; Cysticercosis Working Group in Peru. Neurocysticercosis: updated concepts about an old disease. Lancet Neurol. 2005;4:653-61. doi: 10.1016/S1474-4422(05)70194-0.
Carpio A, Fleury A, Romo ML, Abraham R. Neurocysticercosis: the good, the bad, and the missing. Expert Rev Neurother. 2018;18(4):289-301. doi: 10.1080/14737175.2018.1451328.
Del Brutto OH, García HH. Taenia solium cysticercosis--The lessons of history. J Neurol Sci. 2015;359(1-2):392-5. doi: 10.1016/j.jns.2015.08.011.
Schantz PM, Moore AC, Muñoz JL, Hartman BJ, Schaefer JA, Aron AM, Persaud D, Sarti E, Wilson M, Flisser A. Neurocysticercosis in an Orthodox Jewish community in New York City. N Engl J Med. 1992;327(10):692-5. doi: 10.1056/NEJM199209033271004.
Ndimubanzi PC, Carabin H, Budke CM, Nguyen H, Qian YJ, Rainwater E, et al. A systematic review of the frequency of neurocyticercosis with a focus on people with epilepsy. PLoS Negl Trop Dis. 2010;4(11):e870. doi: 10.1371/journal.pntd.0000870.
Rodriguez S, Díaz-Calderón E, Navas C, Gilman RH, Cuesta F, Mosquera A, Gonzalez AE, Tsang VC, García HH. Epilepsy and neurocysticercosis in Atahualpa: a door-to-door survey in rural coastal Ecuador. Epilepsia. 2005;46(4):583-7. doi: 10.1111/j.0013-9580.2005.36504.x.
Flórez AC, Pastrán SM, Peña AP, Benavides A, Villarreal A, Rincón CE, et al. Cisticercosis en Colombia. Estudio de seroprevalencia 2008-2010. Acta Neurol Colomb. 2011;29(2):9-18.
Flórez AC, Pastrán SM, Peña AP, Villarreal A, Rincón CE, Garzón IP, et al. Cisticercosis en Boyacá Colombia: estudios de seroprevalencia. Acta Neurol Colomb. 2011;27(1):9-18.
Giraldo Forero JC, Riaño Rodríguez MM, Vásquez Arteaga LR. Determinación de la seroprevalencia de cisticercosis porcina e identificación de teniasis humana en personas criadoras de cerdos en el área urbana del municipio de Coyaima Tolima. Rev Med. 2017;25(1):31-45. doi: 10.18359/rmed.2916.
Vásquez-Arteaga LR, Zamora-Bastidas TO, Vivas-Velasco VH, Giraldo-Forero JC, Casas-Zúñiga JC. Epidemiología de la cisticercosis humana en pacientes de consulta neurológica en Popayán, Cauca, Colombia. Med. 2016;38(4):305-15.
Lescano AG, Garcia HH, Gilman RH, Gavidia CM, Tsang VC, Rodriguez S, et al; Cysticercosis Working Group in Peru. Taenia solium cysticercosis hotspots surrounding tapeworm carriers: clustering on human seroprevalence but not on seizures. PLoS Negl Trop Dis. 2009;3(1):e371. doi: 10.1371/journal.pntd.0000371.
Bryceson AD. Neurocysticercosis: A clinical handbook. Brain. 1999;122(2):372-3. doi: 10.1093/brain/122.2.372.
Garcia HH, Nash TE, Del Brutto OH. Clinical symptoms, diagnosis, and treatment of neurocysticercosis. Lancet Neurol. 2014;13(12):1202-15. doi: 10.1016/S1474-4422(14)70094-8.
Raibagkar P, Berkowitz AL. The many faces of neuro-cysticercosis. J Neurol Sci. 2018;390:75-6. doi: 10.1016/j.jns.2018.04.018.
Del Brutto OH. Neurocysticercosis. Handb Clin Neurol. 2014;121:1445-59. doi: 10.1016/B978-0-7020-4088-7.00097-3.
Mejia Maza A, Carmen-Orozco RP, Carter ES, Dávila-Villacorta DG, Castillo G, Morales JD, et al. Axonal swellings and spheroids: a new insight into the pathology of neurocysticercosis. Brain Pathol. 2019;29(3):425-36. doi: 10.1111/bpa.12669.
Del Brutto OH, Del Brutto VJ. Calcified neurocysticercosis among patients with primary headache. Cephalalgia. 2012;32(3):250-4 doi: 10.1177/0333102411433043.
Del Brutto OH. Neurocysticercosis. Continuum (Minneap Minn). 2012;18(6):1392-416. doi: 10.1212/01.CON.0000423853.47770.90.
García HH, Del Brutto OH. Heavy nonencephalitic cerebral cysticercosis in tapeworm carriers. The Cysticercosis Working Group in Perú. Neurology. 1999;53(7):1582-4. doi: 10.1212/wnl.53.7.1582.
Gilman RH, Del Brutto OH, García HH, Martínez M. Prevalence of taeniosis among patients with neurocysticercosis is related to severity of infection. The Cysticercosis Working Group in Perú. Neurology. 2000;55(7):1062. doi: 10.1212/wnl.55.7.1062.
Mahale RR, Mehta A, Rangasetty S. Extraparenchymal (Racemose) neurocysticercosis and its multitude manifestations: A comprehensive review. J Clin Neurol. 2015;11(3):203-11. doi: 10.3988/jcn.2015.11.3.203.
Rana S, Prasad A, Brar R, Rathore DS, Dwivedi A. Caught in the act: migrating intraventricular neurocysticercosis causing intermittent unilateral hydrocephalus due to foramen of Monro obstruction. Acta Neurol Belg. 2018;118(3):509-11. doi: 10.1007/s13760-017-0831-6.
Torres-Corzo J, Rodriguez-Della Vecchia R, Rangel-Castilla L. Bruns syndrome caused by intraventricular neurocys-ticercosis treated using flexible endoscopy. J Neurosurg. 2006;104(5):746-8. doi: 10.3171/jns.2006.104.5.746.
Oudrhiri MY, Raouzi N. Bruns syndrome: a deadly sign. Pan Afr Med J. 2015;22:229. doi: 10.11604/pamj.2015.22.229.8140.
Alsina GA, Johnson JP, McBride DQ, Rhoten PRL, Mehringer CM, Stokes JK. Spinal neurocysticercosis. Neurosurg Focus. 2002;12(6):1-7.
Yacoub HA, Goldstein I, El-Ghanem M, Sharer L, Souayah N. Spinal racemose cysticercosis: case report and review Hosp Pract. 2017;45(3):99-103. doi: 10.1080/21548331.2017.1325704.
Datta SGS, Mehta R, Macha S, Tripathi S. Primary spinal intramedullary neurocysticercosis: a report of 3 cases. World Neurosurg. 2017;105:1037.e1-1037.e7. doi: 10.1016/j.wneu.2017.05.168.
García HH, Del Brutto OH. Imaging findings in neurocysticercosis. Acta Tropica. 2003;87(1):71-8. doi: 10.1016/s0001-706x(03)00057-3.
Kimura-Hayama ET, Higuera JA, Corona-Cedillo R, Chávez-Macías L, Perochena A, Quiroz-Rojas LY, et al. Neurocysticercosis: radiologic-pathologic correlation. Radiographics. 2010;30(6):1705-19. doi: 10.1148/rg.306105522.
Rodacki MA, Detoni XA, Teixeira WR, Boer VH, Oliveira GG. CT features of cellulosae and racemosus neurocysticercosis. J Comput Assist Tomogr. 1989;13(6):1013-6. doi: 10.1097/00004728-198911000-00013.
Coyle CM. Neurocysticerosis: an individualized approach. Infect Dis Clin North Am. 2019;33(1):153-68. doi: 10.1016/j.idc.2018.10.007.
Garcia HH, O'Neal SE, Noh J, Handali S; Cysticercosis Working Group in Peru. Laboratory diagnosis of neurocysticercosis (Taenia solium). J Clin Microbiol. 2018;56(9):e00424-18. doi: 10.1128/JCM.00424-18.
Rodriguez S, Wilkins P, Dorny P. Immunological and molecular diagnosis of cysticercosis. Pathog Glob Health. 2012;106(5):286-98. doi: 10.1179/2047773212Y.0000000048.
Arroyo G, Rodriguez S, Lescano AG, Alroy KA, Bustos JA, Santivañez S, et al; Cysticercosis Working Group in Peru. Antibody banding patterns of the enzyme-linked immunoelectrotransfer blot and brain imaging findings in patients with neurocysticercosis. Clin Infect Dis. 2018;66(2):282-8. doi: 10.1093/cid/cix774.
Carod JF, Randrianarison M, Razafimahefa J, Ramahefarisoa RM, Rakotondrazaka M, Debruyne M, et al. Evaluation of the performance of 5 commercialized enzyme immunoas-says for the detection of Taenia solium antibodies and for the diagnosis of neurocysticercosis. Diagn Microbiol Infect Dis. 2012;72(1):85-9. doi: 10.1016/j.diagmicrobio.2011.09.014.
Garcia HH, Castillo Y, Gonzales I, Bustos JA, Saavedra H, Cob LJ, et al. Low sensitivity and frequent cross-reactions in commercially available antibody-detection ELISA assays for Taenia solium cysticercosis. Trop Med Int Heal. 2018;23(1):101-5. doi: 10.1111/tmi.13010.
Lorenzana P, Corredor A, Díaz C, Murillo C, Duque S, López C. Seguimiento clínico, radiológico e inmunológico de pacientes con neurocisticercosis. Acta Neurol Colomb. 1992;8:123-31.
Murillo C, Díaz C, Lorenzana P, Nicholls S, Corredor A. Detección de antígenos de la larva de Taenia solium mediante la Técnica de ELISA. Rev Colomb Química. 1993;22(1):45-58.
Bobes RJ, Hernández M, Márquez C, Fragoso G, García E, Parkhouse RM, et al. Subarachnoidal and intraventricular human neurocysticercosis: application of an antigen detection assay for the diagnosisand follow-up. Trop Med Int Health. 2006;11(6):943-50. doi: 10.1111/j.1365-3156.2006.01642.x.
Toribio L, Romano M, Scott AL, Gonzales I, Saavedra H, Garcia HH, Shiff C;. Detection of Taenia solium DNA in the urine of neurocysticercosis patients. Am J Trop Med Hyg. 2019;100(2):327-9. doi: 10.4269/ajtmh.18-0706.
Del Brutto OH, Nash TE, White AC, Rajshekhar V, Wilkins PP, Singh G, et al. Revised diagnostic criteria for neurocysticercosis. J Neurol Sci. 2017;372:202-10. doi: 10.1016/j.jns.2016.11.045.
Garcia HH, Gonzalez AE, Gilman RH. Taenia solium cysti-cercosis and its impact in neurological diseas Clin Microbiol Rev. 2020;33(3):e00085-19. doi: 10.1128/CMR.00085-19.
White AC, Coyle CM, Rajshekhar V, Singh G, Hauser WA, Mohanty A, et al. Diagnosis and treatment of neurocysticercosis: 2017 clinical practice guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH). Clin Infect Dis. 2018;66:e49-75. doi: 10.1093/cid/cix1084.
Wu W, Jia F, Wang W, Huang Y, Huang Y. Antiparasitic treatment of cerebral cysticercosis: lessons and experiences from China. Parasltol Res. 2013;112(8):2879-90. doi: 10.1007/s00436-013-3459-3.
Haby MM, Sosa Leon LA, Luciañez A, Nicholls RS, Reveiz L, Donadeu M. Systematic review of the effectiveness of selected drugs for preventive chemotherapy for Taenia solium taeniasis. PLoS Negl Trop Dis. 2020;14(1):e0007873. doi: 10.1371/journal.pntd.0007873.
Román G, Sotelo J, Del Brutto O, Flisser A, Dumas M, Wadia N, et al. A proposal to declare neurocysticercosis anin-ternational reportable disease. Bull World Health Organ. 2000;78(3):399-406.
Allan J, Avila G, Brandr J, Correa D, Del Brutto OH, Dorny P, et al. Guidelines for the surveillance, prevention and control of taeniosis/cysticercosis. WHO/FAO/OIE guidelines for the surveillance, prevention and control of taeniosis/cysticercosis. WHO, FAO, OIE; 2005.
Garcia HH, Gonzalez AE, Tsang VC, O'Neal SE, Llanos-Zavalaga F, Gonzalvez G, et al; Cysticercosis Working Group in Peru. Elimination of Taenia solium Transmission in Northern Peru. N Engl J Med. 2016;374(24):2335-44. doi: 10.1056/NEJMoa1515520.
De Coster T, Van Damme I, Baauw J, Gabriël S. Recent advancements in the control of Taenia solium: A systematic review. Food Waterborne Parasitol. 2018;13. doi: 10.1016/j.fawpar.2018.e00030.
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