Abstract
Chikungunya virus infection has as vector the Aedes family of mosquitos by what is classified as arbovirus, the first reports of the disease date back to several decades, in the Asian continent and although only recently it has spread to the continent American, its rapid spread allows us to know closely the clinical manifestations, among which neurological compromise is less frequent, however its importance lies in the severity of the manifestations at the level of the central nervous system and peripheral; causing great disability in patients. Confirmatory diagnosis is made with the detection of viral RNA by PCR and in most cases the treatment indicated is immunoglobulin. Although, it has not yet been precisely determined, which are the factors by which the virus compromises the nervous system.
References
Lima H de, Nery S, Cordero C, Ribeiro V, Moraes M. Neurochikungunya : a review. Med Res Arch. 2016;4(5). doi: 10.1002/rmv.1978.
Beckham JD, Tyler KL. Arbovirus infections. Contin Lifelong Learn Neurol. 2015;21(6):1599-611. doi: 10.1212/CON.0000000000000240.
Mehta R, Gerardin P, de Brito CAA, Soares CN, Ferreira MLB, Solomon T. The neurological complications of chikungunya virus: A systematic review. Rev Med Virol. 2018;28(3):1-24. doi: 10.1002/rmv.1978.
Do Carmo RL, Simão AKA, Do Amaral LLF, Inada BSY, Silveira CF, Campos CM de S, et al. Neuroimaging of emergent and reemergent infections. Radiographics. 2019;39(6):1649- 71. doi: 10.1148/rg.2019190020.
Cerny T, Schwarz M, Schwarz U, Lemant J, Gérardin P, Keller E. The range of neurological complications in chikungunya fever. Neurocrit Care. 2017;27(3):447-57. doi: 10.1007/s12028-017-0413-8.
Silva S, De Souza W, Washington J, Da Silva D, Fumagalli M. Fatal outcome of chikungunya virus infection in Brazil shirlene. Clin Infect Dis. 2020;7:1-14. doi: 10.1093/cid/ciaa1038.
Rezza G. Chikungunya fever. Emerging infectious diseases: clinical case studies. En: Emerging infectious diseases. Elsevier; 2014. p. 163-174. doi: 10.1016/B978-0-12-416975-3.00012-1.
Mittal A, Mittal S, Bharati J, Ramakrishnan R, Saravanan S, Sathe PS. Optic neuritis associated with chikungunya virus infection in South India. Arch Ophthalmol. 2007;125(10):1381- 6. doi: 10.1001/archopht.125.10.1381.
Valdés López JF, Velilla PA, Urcuqui-Inchima S. Chikungunya virus and zika virus, two different viruses examined with a common aim: Role of pattern recognition receptors on the inflammatory response. J Interf Cytokine Res. 2019;39(9):507-21. doi: 10.1089/jlr.2019.0058.
Economopoulou A, Domínguez M, Helynck B, Sissoko D, Wichmann O, Quenel P, et al. Atypical chikungunya virus infections: Clinical manifestations, mortality and risk factors for severe disease during the 2005-2006 outbreak on Réunion. Epidemiol Infect. 2009;137(4):534-41. doi: 10.1017/S0950268808001167.
Nath A. Neuroinfectious diseases: A crisis in neurology and a call for action. JAMA Neurol. 2015;72(2):143-4. doi: 10.1001/jamaneurol.2014.3442.
Gérardin P, Couderc T, Bintner M, Tournebize P. Chikungunya virus - associated encephalitis. Neurology. 2016;5(86):2005-9. doi: 10.1212/WNL.0000000000002234.
Bomfim E, Sampalo A, Guimaraes E, Corte M, Ramos H. Encephalitis encefalitis:report a fatal case in Northeastern Brazil. . Rev Inst Med Trop Sao Paulo. 2020;62(40):1-5. doi: 10.1590/S1678-9946202062040
Garcia J. Chikungunya. En: CNS infections a clinical approach. Second edition. Springer; 2018. p. 114-6.
Nóbrega PR, Morais NM de M, Braga-Neto P, Barros LS da S, Honório FPP, Dellavance A, et al. NMDAR encephalitis associated with acute chikungunya virus infection: a new trigger? Front Pediatr. 2020;8:8-11. doi: 10.3389/fped.2020.00176
Hameed S, Memon M, Imtiaz H, Kanwar D. Longitudinally extensive transverse myelitis with seropositive chikungunya. BMJ Case Rep. 2019;12(10):e231745. doi: 10.1136/bcr-2019-231745.
Brito Ferreira ML, Militão de Albuquerque M de FP, de Brito CAA, de Oliveira França RF, Porto Moreira ÁJ, de Morais Machado MI, et al. Neurological disease in adults with Zika and chikungunya virus infection in Northeast Brazil: a prospective observational study. Lancet Neurol. 2020;19(10):826-39. doi: 10.1016/1474-4422(20)30232-5.
Rodrigues A, Fernandes L, Pires R. Acute disseminated encephalomyelitis after chikungunya infection. JAMA Neurol. 2019;76(5). doi: 10.1016/S1474-4422(20)30232-5.
Wielanek AC, Monredon J De, Amrani M El, Roger JC, Serveaux JP. Guillain-Barré syndrome complicating a Chi-kungunya virus infection. Neurology. 2007;27(22):2105-7. doi: 10.1212/01.wnl.0000277267.07220.88.
Complicando a infecção pelo vírus chikungunya. J Neurovirol. 2017;23:504-7.
De Sousa M, Rodrigues T, Frota G. Guillain-Barre syndrome and its correlation with dengue, Zika and chikungunya viruses infection based on a literature review of reported cases in Brazil. Acta Trop. 2019;197:105064. doi: 10.1016/j.actatro-pica.2019.105064.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.