Resumen
INTRODUCCIÓN:El temblor esencial es el temblor más común. No se ha descrito la asociación entre diabetes y temblor esencial. El objetivo de este estudio de casos y controles es documentar la asociación entre diabetes mellitus y temblor esencial.
MÉTODOS:Se realizó un estudio de casos y controles en población clínica de pacientes incidentes con temblor esencial, pareados por edad y género, a quienes se les interrogó sobre antecedente de diabetes mellitus. Se determinó el OR mediante regresión logística condicionada.
RESULTADOS:Se estudiaron 262 casos de temblor esencial y 262 controles. El antecedente de diabetes mellitus se encontró en 39 casos con temblor esencial y en 24 controles, lo que representa una asociación positiva entre los dos (OR 2,15, IC95 % 1,05 a 4,41).
DISCUSIÓN:Este estudio de casos y controles en una población clínica muestra que los pacientes con temblor esencial tienen dos veces más probabilidad de tener el antecedente de diabetes mellitus.
Citas
Romero JP, Benito-León J, Bermejo-Pareja F. The NEDICES study: recent advances in the understanding of the epidemiology of essential tremor. Tremor Other Hyperkinet Mov 2012;2: Disponible en: http://tremorjournal.org/article/view/70.
Zesiewicz TA, Elble R, Louis ED, Hauser RA, Sullivan KL, Dewey RB, Ondo WG, et al. Practice parameter: therapies for essential tremor report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2005;64:2008-20.
Frishman WH, Saunders E. ?-Adrenergic blockers. J Clin Hypertens (Greenwich). 2011;13(9):649-53.
Li J, Cesari M, Liu F, Dong ?, Vellas ?. Effects of diabetes mellitus on cognitive decline in patients with Alzheimer disease: a systematic review. Can J Diabetes. 2017;41(1):114-9.
Deuschl G, Bain P, Brin M; Ad Hoc Scientific Committee. Consensus statement of the movement disorder society on tremor. Mov Disord. 1998; 13(Supl. 3):2-23.
Keogh RH, Cox DR. Introduction to case-control studies. En Keogh RH, Cox DR, editors. Case-control studies. Cambridge University Press; 2014. p. 8-30.
Pourhoseingholi MA, Baghestani AR, Vahedi M. How to control confounding effects by statistical analysis. Gastroenterol Hepatol Bed Bench. 2012;5(2):79-83.
Deng H, Le W, Jankovic J. Genetics of essential tremor. Brain 2007; 130:1456-64.
Louis ED. Environmental epidemiology of essential tremor. Neuroepidemiology. 2008;31:139-49.
Lucchini RG, Hashim D. Tremor secondary to neurotoxic exposure: mercury, lead, solvents, pesticides. En Lotti M, BNleecker MI, editores. Handbook of clinical neurology, vol. 131 (3rd series). Occupational Neurology. Elsevier BV; 2015. p. 241-9.
Louis ED, Zheng W, Jurewicz EC, Watner D, Chen J, Factor-Litvak P, Parides M. Elevation of blood ?-carboline alkaloids in essential tremor. Neurology 2002;59:1940-4.
Louis ED, Zheng W, Applegate L, Shi L, Factor-Litvak P. Blood harmane concentrations and dietary protein consumption in essential tremor. Neurology. 2005;65:391-6.
Louis ED, Jurewicz EC, Applegate L, Factor-Litvak P, Parides M, Andrews L, Slavkovich V, Graziano JH, Carroll S, Todd A. Association between essential tremor and blood lead concentration. Environ Health Perspect. 2003;111:1707-11.
Dogu O, Louis ED, Tamer L, Unal O, Yilmaz A, Kaleagasi H. Elevated blood lead concentrations in essential tremor: a case-control study in Mersin, Turkey. Environ Health Perspect. 2007;115:1564-8.
Louis ED, Factor-Litvak P, Parides M, Andrews L, Santella RM, Wolff MS. Organochlorine pesticide exposure in essential tremor: a case-control study using biological and occupational exposure assessments. Neurotoxicology. 2006;27:579-86.
Jiménez-Jiménez FJ, de Toledo-Heras M, Alonso-Navarro H, Ayuso-Peralta L, Arévalo-Serrano J, Ballesteros-Barranco A, Puertas I, Jabbour-Wadih T, Barcenilla ?. Environmental risk factors for essential tremor. Eur Neurol. 2007;58:106-13.
Keezer MR, Wolfson C, Postuma RB. Age, gender, comorbidity, and the MDS-UPDRS: results from a population-based study. Neuroepidemiology. 2016;46(3):222-7.
Louis ED. Essential tremors. A family of neurodegenerative disorders? Arch Neurol. 2009;66(10):1202-8.
LaRoia H, Louis ED. Association between essential tremor and other neurodegenerative diseases: what is the epidemiological evidence? Neuroepidemiology. 2011;37:1-10.
Mittal K, Katare DP. Shared links between type 2 diabetes mellitus and Alzheimer's disease: a review. Diabetes Metab Syndr. 2016;10(2 Supl. 1):S144-9.
Yang Y-W, Hsieh T-F, Li C-I, Liu C-S, Lin W-Y, Chiang J-H, Li T-C, et al. Increased risk of Parkinson disease with diabetes mellitus in a population-based study. Medicine (Baltimore). 2017;96(3):e5921.
Yue X, Li H, Yan H, Zhang P, Chang L, Li T. Risk of Parkinson disease in diabetes mellitus: an updated meta-analysis of population-based cohort studies. Medicine (Baltimore). 2016;95(18):e3549.
Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín ?, Agúndez JAG. The relationship between Parkinson's disease and essential tremor: review of clinical, epidemiologic, genetic, neuroimaging and neuropathological data, and data on the presence of cardinal signs of parkinsonism in essential tremor. Tremor Other Hyperkinet Mov 2012;2. Disponible en: http://tremorjournal.org/article/view/75.
McClean PL, Gault VA, Harriott P, Hõlscher C. Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease. Eur J Pharmacol. 2010;630(1-3):158-62.
Duffy AM, Hõlscher C. The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer's disease. Neuroscience. 2013;228:294-300.
Abboud H, Ahmed A, Fernandez HH. Essential tremor: Choosing the right management plan for your patient. Cleve Clin J Med. 2011;78(12):821-8.
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.