Autismo y epilepsia
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Keywords

autistic
disorder
epilepsy

Abstract

Multiple studies have started the greater risk of autistic population of suffering epileptic seizures. The association of epilepsy and autism can consider between 7-42 percent. In autism, epilepsy has two tips of frequency, during the first three years of life and in the puberty; girls present more epilepsy than boys do.

Diverse types of seizures have been described: partial complex, infantile spasms, atonics, mioclonics, atypical absences and generalized tonic-clonic seizures. The epileptiforme activity is located predominantly in temporal, central, frontal and occipitals areas. Studies with magneto encephalography in autism have emphasized a high prevalence of subclinical epileptiforme activity in 82-92 percent of patients; nevertheless all patients present unusual behaviors that can consider as subclinical crisis. The epileptiforme activity in the perisylvian area predominates in the left hemisphere, fact that would explain the lack of acquisition of cognitive, communicative, and social aspects of behavior


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References

Kanner L. Autistic disturbances of affective contact. Nervous Child 1943; 10: 217-50.

Muñoz Yunta JA. Guía Médica y Neuropsicológica del Autismo. Barcelona: Fundació Autisme Mas Casadevall, F. P; 2005: 17-27.

Spitz RA. Hospitalism: Inquiry into genesis of psychiatric conditions in early childhood. Psychoanalytic Study of the Child 1945; 1: 53-74.

Schain RJ, Yannet H. Infantile autism. An analysis of 50 cases and a consideration of certain relevant neurophysiologic concepts. Journal of Pediatrics 1960; 57: 560-67.

Deykin E, MacMahon B. The incidence of seizures among children with autistic symptoms. American Journal of Psychiatry 1979; 136: 1310-2.

Chess S. Follow-up report on autism in congenital rubella. Journal of Autism and Childhood Schizophrenia 1977; 7: 69-81.

DeMyer MK, Pontius W, Norton JA, Barton S, Allen J, Steele R. Parental practices and innate activity in normal, autistic, and brain-damaged infants. Journal of Autism and Childhood Schizophrenia 1972; 2: 49-66.

Cantwell DP, Baker L, Rutter M. Families of autistic and dysphasic children. I. Family life and interaction patterns. Archives of General Psychiatry 1979; 36: 682-87.

Kanner L. Follow-up study of eleven autistic children originally reported in 1943. J Autism Child Schizophr 1971; 1:119-45.

Wong V. Epilepsy in children with autistic spectrum disorder. J Child Neurol 1993; 8:316-22.

Muñoz Yunta JA, Salvadó B, Ortiz Alonso T, Amo C, Fernández Lucas A, Maestú F, Palau Baduell M. Clínica de la epilepsia en los trastornos del espectro autista. Rev Neurol 2003; 36 (Supl 1): S61-67.

Canitano R, Luchetti A, Zapella M. Epilepsy, electroencephalographic abnormalities, and regression in children with autism. J Child Neurol 2005; 20:27-31.

Reinhold JA, Molloy CA, Manning-Courtney P. Electroencephalogram abnormalities in children with autism spectrum disorders. J Neurosci Nurs 2005; 37:136-8.

Gabis L, Pomeroy J, Andriola MR. Autism and epilepsy: cause, consequence, comorbidity, or coincidence?. Epilepsy Behav 2005; 7: 652-656.

Hughes JR, Melyn M. EEG and seizures in autistic children and adolescents: further findings with therapeutic implications. Clin EEG Neurosci 2005; 36: 15-20.

Carod FJ, Prats JM, Garaizar C, Zuazo E. Clinical-radiological evaluation of infantile autism and epileptic syndromes associated with autism. Rev Neurol 1995; 23:1203-7.

Ritvo ER, Freeman BJ, Pingree C, Mason-Brothers A, Jorde L, Jenson WR et al. The UCLA-University of Utah epidemiologic survey of autism: prevalence. Am J Psychiatry 1989; 146:194-9.

Gillberg C, Steffenburg S. Outcome and prognostic factors in infantile autism and similar conditions: a population-based study of 46 cases followed through puberty. J Autism Dev Disord 1987;17:273-87.

Tuchman RF, Rapin I, Shinnar S. Autistic and dysphasic children. II: Epilepsy. Pediatrics 1991; 88:1219-25.

Elia M, Musumeci SA, Ferri R, Bergonzi P. Clinical and neurophysiological aspects of epilepsy in subjects with autism and mental retardation. Am J Ment Retard 1995; 100:6-16.

Gillberg C, Coleman M. The Biology of the Autistic Syndromes. London: Mac Keith Press; 2000: 185-196.

Riikonen R, Amnell G. Psychiatric disorders in children with earlier infantile spasms. Dev Med Child Neurol 1981; 23:747-60.

Hunt A, Dennis J. Psychiatric disorder among children with tuberous sclerosis. Dev Med Child Neurol 1987; 29: 190-8.

Taft LT, Cohen HJ. Hypsarrhythmia and infantile autism: a clinical report. J Autism Child Schizophr 1971; 1: 327-36.

Millichap JG. Progress in Pediatric Neurology III. Chicago: PNB Publishers; 1997:41.

Ohtsuka Y, Ohmori I, Oka E. Long-term follow-up of childhood epilepsy associated with tuberous sclerosis. Epilepsia 1998; 39: 1158-63.

Chugani HT, Da Silva E, Chugani DC. Infantile spasms: III. Prognostic implications of bitemporal hypometabolism on positron emission tomography. Ann Neurol 1996; 39: 643-9.

Muñoz Yunta JA, Freixas A, Valls Santasusana A, Maldonado A. Epilepsia del desarrollo y estudios mediante tomografía por emisión de positrones cerebral. Rev Neurol Clin 2000; 1: 45- 54.

Kagan-Kushnir T, Roberts SW, Snead OC 3rd. Screening electroencephalograms in autism spectrum disorders: evidence-based guideline. J Child Neurol 2005; 20: 197-206.

Muñoz Yunta J A et al. Guía Médica y Neuropsicológica del Autismo. Barcelona: Fundació Autisme Mas Casadevall, F. P; 2005: 171-185.

Etchepareborda MC. Tratamiento de los niños con electroencefalograma paroxístico sin crisis. Rev Neurol 2003; 37: 293-297.

Lewine JD, Andrews R, Chez M, Patil AA, Devinsky O, Smith M, et al. Magnetoencephalographic patterns of epileptiform activity in children with regressive autism spectrum disorders. Pediatrics 1999; 104 (3 Pt 1):

-18.

Tuchman RF, Rapin I. Regression in pervasive developmental disorders: seizures and epileptiform electroencephalogram correlates. Pediatrics 1997; 99:560-6.

Gillberg C, Schaumann H. Epilepsy presenting as infantile autism? Two case studies. Neuropediatrics 1983; 14:206-12.

Landau WM, Kleffner FR. Syndrome of acquired aphasia with convulsive disorder in children. 1957. Neurology 1998; 51: 1241-8.

Takeoka M, Riviello JJ Jr, Duffy FH, et al. Bilateral volume reduction of the superior temporal areas in Landau- Kleffner syndrome. Neurology 2004; 63: 1289-92.

Deonna TW. Acquired epileptiform aphasia in children (Landau-Kleffner syndrome). J Clin Neurophysiol 1991; 8:288-98.

Tuchman RF, Moshé SL, Rapin I. Trastornos del neurodesarrollo y epilepsia. Rev Neurol 2005; 40 (Supl 1): S3-S10.

Bolton PF, Park RJ, Higgins JN, et al. Neuro- epileptic determinants of autism spectrum disorders in tuberous sclerosis complex. Brain 2002; 125 (Pt6): 1247-55.

Smalley SL. Autism and tuberous sclerosis. J Autism Dev Disord 1998; 28: 407-14.

Percy AK. Rett syndrome. Current status and new vistas. Neurol Clin 2002; 20: 1125-41.

Horike S, Cai S, Miyano M, Cheng JF, Kohwi- Shigematsu T. Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome. Nat Genet 2005; 37: 31-40.

Berry-Kravis E. Epilepsy in fragile X syndrome.

Dev Med Child Neurol 2002; 44: 724-8.

Galván-Manso M, Campistol J, Monros E, Póo P, Vernet AM, Pineda M, Sans A, Colomer J, Conill J, Sanmartí FX. Síndrome de Angelman: características físicas y fenotipo conductual en 37 pacientes con diagnóstico genético confirmado. Rev Neurol 2002; 35: 425-29.

Cersósimo R, Caraballo R, Espeche A, Cassar L, Torrado MV, Chertkoff L, Baialardo E, Arroyo H, Fejerman N. Síndrome de Angelman: características electroclínicas en 35 pacientes. Rev Neurol 2003; 37: 14-18.

Weiss LA, Escayg A, Kearney JA, et al. Sodium channels SCN1A, SCN2A and SCN3A in familial autism. Mol Psychiatry 2003; 8: 186-94.

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