Tratamiento de la neuropatía sensitiva dolorosa asociada al VIH
DOI:
https://doi.org/10.22379/2422402279Palabras clave:
Neuropatía periférica sensitiva, Tratamiento (DeCS)Resumen
Se presenta una revisión de los estudios aleatorizados a doble ciego y controlados con placebo, publicados en la literatura científica sobre el tratamiento farmacológico y con terapias complementarias de la neuropatía periférica dolorosa, asociada al virus de la inmunodeficiencia humana adquirida (VIH), publicados entre enero de 1996 y octubre de 2015. Se localizaron 219 artículos y se seleccionaron para análisis 20 estudios.
Los 20 estudios seleccionados incluyeron 2.246 pacientes con neuropatía sensitiva distal asociada a HIV (HIV-SN) característicamente dolorosa, en la forma de polineuropatía sensitiva distal (DSP) o neuropatía por antiretrovirales (ATN) y correspondieron a estudios controlados.
Los resultados de esta revisión muestran la eficacia de la capsaicina al 8%, el cannabis fumado y el factor de crecimiento neural recombinante humano (rhNGF) en el manejo del dolor de la DSP. La lamotrigina y la acetilcarnitina son medicaciones prometedoras en la ATN de los pacientes con HIV. Sin embargo, es necesaria la búsqueda de nuevas estrategias terapéuticas en el manejo de la DSP y la ATN.
Biografía del autor/a
Natalia Hernández-Beltrán, Fundación Cardioinfantil
Médica-Residente de neurología de III año. Fundación Cardioinfantil. Universidad del Rosario. Bogotá.
Carlos B. Moreno, Universidad del Rosario
Médico neurofisiólogo, Unidad de Neurociencia, Grupo de investigación Neuros, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario. Bogotá.
John Hernández , Universidad del Rosario
Médico neurocirujano, algesiólogo y paliativista. MEDERI Grupo de investigación Neuros, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario. Bogotá.
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